Bbc3 - BCL2 binding component 3 Gene

Mus musculus

Also known as PUMA; PUMA/JFY1

Gene ID: 170770 | Gene type: protein coding

About Bbc3

Summary

Predicted to enable ATPase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and toxin transport. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Apr 2022]

Bbc3 Products(9)

mRNA	Protein	Name
NM_001382549.1	NP_001369478.1	bcl-2-binding component 3 isoform a
NM_001382550.1	NP_001369479.1	bcl-2-binding component 3 isoform a
NM_001382552.1	NP_001369481.1	bcl-2-binding component 3 isoform a
NM_001403671.1	NP_001390600.1	bcl-2-binding component 3 isoform a
NM_001403672.1	NP_001390601.1	bcl-2-binding component 3 isoform a
NM_001403673.1	NP_001390602.1	bcl-2-binding component 3 isoform a
NM_001403674.1	NP_001390603.1	bcl-2-binding component 3 isoform b
NM_001403675.1	NP_001390604.1	bcl-2-binding component 3 isoform c
NM_133234.3	NP_573497.1	bcl-2-binding component 3 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16151013	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IGI IGI: Inferred from genetic interaction	20818388	MGI
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
acts upstream of or within cellular response to ionizing radiation	IGI IGI: Inferred from genetic interaction	16286009	MGI
involved in determination of adult lifespan	IGI IGI: Inferred from genetic interaction	20818388	MGI
acts upstream of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	16151013	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	16407291	MGI
acts upstream of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within positive regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
involved in positive regulation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	21159964	MGI
acts upstream of positive regulation of establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	16705087	MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	16705087	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21159964	MGI
involved in positive regulation of thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	20818388	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	21159964	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bcl-2-binding component 3

BH3-only	Bcl-2 binding component 3
p53 up-regulated modulator of apoptosis

Bbc3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bbc3	Q99ML1	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	16151013

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01381	BBC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bbc3	NCBI	NCBI:27113

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