Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Gene

Rattus norvegicus

Gene ID: 170911 | Gene type: protein coding

About Pik3ca

Primary_assembly 2: 115,174,984-115,249,032 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 275 orthologues, 9 paralogues and is associated with 111 phenotypes. Biased expression in Thymus (RPKM 217.1), Lung (RPKM 214.6) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to dexamethasone; and response to leucine. Part of phosphatidylinositol 3-kinase complex. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast Cancer (multiple); cutaneous Paget's disease; and gastrointestinal system Cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3ca Products(1)

mRNA	Protein	Name
NM_133399.3	NP_596890.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	12882977	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14724584	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28947594	RGD
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	12882977	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25908763	RGD
involved in response to L-leucine	IEP IEP: Inferred from expression pattern	24124592	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	23812090	RGD
involved in response to butyrate	IEP IEP: Inferred from expression pattern	24124592	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	24124592	RGD
involved in response to muscle inactivity	IEP IEP: Inferred from expression pattern	24124592	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of phosphatidylinositol 3-kinase complex	IDA IDA: Inferred from direct assay	12882977	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3ca Protein Structure

PI3K_p85B

PI3K_rbd

C2_PI3K_class_I_alpha

PI3Ka_I

PI3Kc_IA_alpha

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1068 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PI3-kinase subunit alpha	PI3K-alpha
PI3Kalpha	p110alpha
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
phosphoinositide-3-kinase catalytic alpha polypeptide	ptdIns-3-kinase subunit alpha
ptdIns-3-kinase subunit p110-alpha	serine/threonine protein kinase PIK3CA

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15244	Alpelisib	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13898	Taselisib	Inhibitor	99.75%	Phase 3
HY-10358	MK-2206 dihydrochloride		99.99%	Phase 2
HY-108232	MK-2206		/	Phase 2
HY-10357	MK-2206 free base		/	Phase 2
HY-153306	RLY-2608	Inhibitor	99.20%	Phase 1
HY-100886	BAY1082439		98.02%	Phase 1
HY-137458	Vevorisertib	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	99.13%	Unkown
HY-126077	MTI-31	Inhibitor	99.98%	Unkown
HY-RS10523	PIK3CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-RS10524	Pik3ca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10525	Pik3ca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116191	WJD008	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3ca	NCBI	NCBI:5290

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