2. Gene
  3. Slc6a5 - solute carrier family 6 member 5 Gene

Slc6a5 - solute carrier family 6 member 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as GLYT2

Gene ID: 171148 | Gene type: protein coding

About Slc6a5

Primary_assembly 1: 99,645,389-99,697,010 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 210 orthologues, 20 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 649.2).

Summary

Enables glycine transmembrane transporter activity. Involved in glycine transport and neurotransmitter uptake. Located in dense core granule and endosome. Is active in glycinergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a5 Products(1)

mRNA Protein Name
NM_203334.1 NP_976079.1 sodium- and chloride-dependent glycine transporter 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glycine transmembrane transporter activity IDA
IDA: Inferred from direct assay
8226790 RGD
enables glycine:sodium symporter activity IDA
IDA: Inferred from direct assay
8226790 RGD
Biological Process GO Annotation Evidence Reference Source
involved in glycine transport IDA
IDA: Inferred from direct assay
8226790 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dense core granule IDA
IDA: Inferred from direct assay
12091465 RGD
located in endosome IDA
IDA: Inferred from direct assay
12091465 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
7751957 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
7751957 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a5 Protein Structure

SLC6sbd_GlyT2

SLC6sbd_GlyT2: cd11499 (192 - 788)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
Protein Preferred Names Protein Names

sodium- and chloride-dependent glycine transporter 2

glyT-2

glycine transporter 2

solute carrier family 6 (neurotransmitter transporter), member 5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13314 SLC6A5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13315 Slc6a5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13316 Slc6a5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a5 NCBI NCBI:9152