Mc3r - melanocortin 3 receptor Gene

Mus musculus

Also known as MC3-R

Gene ID: 17201 | Gene type: protein coding

About Mc3r

Chromosome 2: 172,090,412-172,093,034 forward strand.GRCm39:CM000995.3

This gene has 1 transcript (splice variant), 141 orthologues, 18 paralogues and is associated with 42 phenotypes.

Summary

This gene encodes a member of the Melanocortin Receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide Hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on Insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]

Mc3r Products(1)

mRNA	Protein	Name
NM_008561.3	NP_032587.1	melanocortin receptor 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables melanocyte-stimulating hormone receptor activity	IDA IDA: Inferred from direct assay	9454589	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9454589	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19036988	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	19036988	MGI
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	19036988	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

melanocortin receptor 3

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147301	Resomelagon	Agonist	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P1214	γ1-MSH	Agonist	99.71%	Unkown
HY-P1217	[D-Trp8]-γ-MSH	Agonist	99.57%	Unkown
HY-P1531	γ-1-Melanocyte Stimulating Hormone (MSH), amide	Agonist	99.32%	Unkown
HY-P1209A	PG106 TFA	Antagonist	98.13%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P1217A	[D-Trp8]-γ-MSH TFA	Agonist	/	Unkown
HY-P1214A	γ1-MSH TFA	Agonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown
HY-168383	(E/Z)-Resomelagon acetate	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc3r	NCBI	NCBI:4159

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