Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Mus musculus

Also known as AGT; Agat

Gene ID: 17314 | Gene type: protein coding

About Mgmt

Chromosome 7: 136,496,343-136,731,995 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 189 orthologues and is associated with 9 phenotypes. Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.) and 24 other tissues.

Summary

Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products(10)

mRNA	Protein	Name
NM_001412701.1	NP_001399630.1	methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001412704.1	NP_001399633.1	methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412703.1	NP_001399632.1	methylated-DNA--protein-cysteine methyltransferase isoform 5
NM_001412698.1	NP_001399627.1	methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412702.1	NP_001399631.1	methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001377037.2	NP_001363966.1	methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412697.1	NP_001399626.1	methylated-DNA--protein-cysteine methyltransferase isoform 2
NM_008598.4	NP_032624.1	methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412699.1	NP_001399628.1	methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412700.1	NP_001399629.1	methylated-DNA--protein-cysteine methyltransferase isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables methyltransferase activity	IDA IDA: Inferred from direct assay	1554415	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA alkylation repair	IDA IDA: Inferred from direct assay	1554415	MGI
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	9560238	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	13679151	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	13679151	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgmt Protein Structure

AdaB

0
100
211 a.a.

Protein Preferred Names

Protein Names

methylated-DNA--protein-cysteine methyltransferase

6-O-methylguanine-DNA methyltransferase	O-6-alkylguanine-DNA alkyltransferase
O-6-methylguanine-DNA-alkyltransferase

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13668	Lomeguatrib	Inhibitor	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13057	O6BTG-octylglucoside	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mgmt	NCBI	NCBI:4255

Name
Email *

	Sorry, but the email address you supplied was invalid.