Mknk1 - MAP kinase-interacting serine/threonine kinase 1 Gene

Mus musculus

Also known as Mnk1; 2410048M24Rik

Gene ID: 17346 | Gene type: protein coding

About Mknk1

Chromosome 4: 115,696,395-115,736,447 forward strand.GRCm39:CM000997.3

This gene has 14 transcripts (splice variants), 166 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues.

Summary

This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Mknk1 Products(5)

mRNA	Protein	Name
NM_001355174.1	NP_001342103.1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform c
NM_021461.5	NP_067436.1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285488.1	NP_001272417.1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285487.1	NP_001272416.1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform a
NM_001369238.1	NP_001356167.1	MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9155017	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9155017	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	17903173	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17903173	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9155017	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9155017	MGI
involved in response to salt stress	IDA IDA: Inferred from direct assay	9155017	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mknk1 Protein Structure

STKc_Mnk1

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

MAP kinase-interacting serine/threonine-protein kinase 1

MAPK signal-integrating kinase 1

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08473	MKNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08474	Mknk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08475	Mknk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mknk1	NCBI	NCBI:8569

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