Mmp14 - matrix metallopeptidase 14 (membrane-inserted) Gene

Mus musculus

Also known as sabe; MMP-X1; MT1-MMP; MT-MMP-1

Gene ID: 17387 | Gene type: protein coding

About Mmp14

Chromosome 14: 54,669,069-54,682,821 forward strand.GRCm39:CM001007.3

This gene has 7 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 113 phenotypes. Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 1.7) and 24 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]

Mmp14 Products(1)

mRNA	Protein	Name
NM_008608.4	NP_032634.3	matrix metalloproteinase-14 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	21572390	MGI
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	10737763	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within bone development	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15572153	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	15572153	MGI
acts upstream of or within chondrocyte proliferation	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within collagen catabolic process	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within craniofacial suture morphogenesis	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within endochondral ossification	IGI IGI: Inferred from genetic interaction	18022611	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	15572153	MGI
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21572390	MGI
acts upstream of or within ossification	IGI IGI: Inferred from genetic interaction	18022611	MGI
involved in positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	21572390	MGI
involved in positive regulation of macrophage migration	IMP IMP: Inferred from mutant phenotype	24990232	MGI
involved in positive regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	21572390	MGI
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	10737763	MGI
acts upstream of or within zymogen activation	IMP IMP: Inferred from mutant phenotype	15572153	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp14 Protein Structure

PG_binding_1

Peptidase_M10

DUF3377

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-14

Membrane type 1-MMP	matrix metalloproteinase 14 (membrane-inserted)
membrane-type-1 matrix metalloproteinase	type 1 matrix metalloprotease 14

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15827	NSC 405020	Inhibitor	99.67%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-124373	ND-336	Inhibitor	95.4%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	/	Unkown
HY-P3120	Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2		96.30%	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-162038	RXP03	Inhibitor	/	Unkown
HY-E70290	N-Acetylgalactosaminyltransferase 1	Agonist	/	Unkown
HY-RS08528	MMP14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08529	Mmp14 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08530	Mmp14 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp14	NCBI	NCBI:4323

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