2. Metabolic Enzyme/Protease
  3. MMP
  4. ND-336

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.

For research use only. We do not sell to patients.

ND-336 Chemical Structure

ND-336 Chemical Structure

CAS No. : 1807453-83-3

Size Price Stock Quantity
500 μg In-stock
1 mg In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ND-336:

ND-336 Related Antibodies

Top Publications Citing Use of Products

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].

IC50 & Target[1]

MMP-2

85 nM (Ki)

MMP-9

150 nM (Ki)

MMP-14

120 nM (Ki)

In Vivo

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition[1].
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female diabetic db/db mice[1]
Dosage: 0.05, 0.025, and 0.01 mg
Administration: Topical application; daily for 14 day
Result: Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
Molecular Weight

371.90

Formula

C16H18ClNO3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (80.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6889 mL 13.4445 mL 26.8889 mL
5 mM 0.5378 mL 2.6889 mL 5.3778 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.4%

SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6889 mL 13.4445 mL 26.8889 mL 67.2224 mL
5 mM 0.5378 mL 2.6889 mL 5.3778 mL 13.4445 mL
10 mM 0.2689 mL 1.3444 mL 2.6889 mL 6.7222 mL
15 mM 0.1793 mL 0.8963 mL 1.7926 mL 4.4815 mL
20 mM 0.1344 mL 0.6722 mL 1.3444 mL 3.3611 mL
25 mM 0.1076 mL 0.5378 mL 1.0756 mL 2.6889 mL
30 mM 0.0896 mL 0.4481 mL 0.8963 mL 2.2407 mL
40 mM 0.0672 mL 0.3361 mL 0.6722 mL 1.6806 mL
50 mM 0.0538 mL 0.2689 mL 0.5378 mL 1.3444 mL
60 mM 0.0448 mL 0.2241 mL 0.4481 mL 1.1204 mL
80 mM 0.0336 mL 0.1681 mL 0.3361 mL 0.8403 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ND-336 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ND-3361807453-83-3ND336ND 336MMPMatrix metalloproteinaseswoundhealinginflammationangiogenesisselectivediabeticInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ND-336
Cat. No.:
HY-124373
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.