DMBT1 - deleted in malignant brain tumors 1 Gene

Homo sapiens

Also known as SAG; GP340; SALSA; muclin

Gene ID: 1755 | Gene type: protein coding

About DMBT1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:122,560,754-122,643,736 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and 15 paralogues. Biased expression in duodenum (RPKM 482.0), small intestine (RPKM 157.2) and 1 other tissue.

Summary

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

DMBT1 Products(5)

mRNA	Protein	Name
NM_001320644.2	NP_001307573.1	deleted in malignant brain tumors 1 protein isoform d precursor
NM_001377530.1	NP_001364459.1	deleted in malignant brain tumors 1 protein isoform e precursor
NM_004406.3	NP_004397.2	deleted in malignant brain tumors 1 protein isoform a precursor
NM_007329.3	NP_015568.2	deleted in malignant brain tumors 1 protein isoform b precursor
NM_017579.3	NP_060049.2	deleted in malignant brain tumors 1 protein isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables heparan sulfate binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	19189310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10101009	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	19189310	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	11007786	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	19189310	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	11007786	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in induction of bacterial agglutination	IDA IDA: Inferred from direct assay	11007786	GOA
involved in induction of bacterial agglutination	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	19189310	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10485905	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11007786	GOA
located in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	10485905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMBT1 Protein Structure

SRCR

CUB

SRCR

CUB

Zona_pellucida

0
400
800
1200
1600
2000
2413 a.a.

Protein Preferred Names

Protein Names

deleted in malignant brain tumors 1 protein

glycoprotein 340

Recombinant DMBT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75710	DMBT1 Protein, Human (HEK293, His)	Q9UGM3/NP_004397.2 (T20-S220)	≥95%

Related Diseases

Diseases

Alias

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Glioma

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Enamel Caries

Primary Dental Caries	Dental Caries Limited To Enamel
Simple Dental Cavity

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03820	DMBT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DMBT1	VGNC	VGNC:39996
Mus musculus	DMBT1	MGD	MGI:106210
Rattus norvegicus	DMBT1	RGD	RGD:61984

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