TRDMT1 - tRNA aspartic acid methyltransferase 1 Gene

Homo sapiens

Also known as DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP

Gene ID: 1787 | Gene type: protein coding

About TRDMT1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:17,137,336-17,201,672 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 1.0), endometrium (RPKM 0.6) and 25 other tissues.

Summary

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This Enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

TRDMT1 Products(8)

mRNA	Protein	Name
NM_001321006.2	NP_001307935.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform f
NM_001321007.2	NP_001307936.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform g
NM_001351219.2	NP_001338148.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform h
NM_001351220.2	NP_001338149.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform i
NM_001351221.2	NP_001338150.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform j
NM_001351222.2	NP_001338151.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform k
NM_001351223.2	NP_001338152.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform k
NM_004412.7	NP_004403.1	tRNA (cytosine(38)-C(5))-methyltransferase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tRNA (cytidine-5-)-methyltransferase activity	EXP EXP: Inferred from Experiment	16424344	GOA
enables tRNA (cytidine-5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	16424344	GOA
enables tRNA methyltransferase activity	IDA IDA: Inferred from direct assay	16424344	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within tRNA methylation	IDA IDA: Inferred from direct assay	16424344	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	16424344	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16424344	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRDMT1 Protein Structure

DNA_methylase

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

tRNA (cytosine(38)-C(5))-methyltransferase

DNA (cytosine-5)-methyltransferase-like protein 2

Recombinant TRDMT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75711	DNMT2 Protein, Human (sf9, GST)	O14717 (M1-E391)	≥95%

Related Diseases

Diseases

Alias

Dubowitz Syndrome

Dubowitz'S Syndrome	Dwarfism-Eczema-Peculiar Facies Syndrome
Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14999	TRDMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRDMT1	VGNC	VGNC:36296
Rattus norvegicus	TRDMT1	RGD	RGD:1306292
Mus musculus	TRDMT1	MGD	MGI:1274787
Canis familiaris	TRDMT1	VGNC	VGNC:47790
Macaca mulatta	TRDMT1	VGNC	VGNC:106112
Others	TRDMT1	NCBI

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