Npy5r - neuropeptide Y receptor Y5 Gene

Mus musculus

Also known as Y5R; NPY5-R; NPYY5-R

Gene ID: 18168 | Gene type: protein coding

About Npy5r

Chromosome 8: 67,132,617-67,140,780 reverse strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 137 orthologues, 55 paralogues and is associated with 16 phenotypes. Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 1.) and 5 other tissues.

Summary

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r Products(3)

mRNA	Protein	Name
NM_001358957.1	NP_001345886.1	neuropeptide Y receptor type 5
NM_001358958.1	NP_001345887.1	neuropeptide Y receptor type 5
NM_016708.3	NP_057917.2	neuropeptide Y receptor type 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide Y receptor activity	IDA IDA: Inferred from direct assay	9802393	MGI
enables pancreatic polypeptide receptor activity	IDA IDA: Inferred from direct assay	9802393	MGI
enables peptide YY receptor activity	IDA IDA: Inferred from direct assay	9802393	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10557353	MGI
involved in synaptic signaling via neuropeptide	EXP EXP: Inferred from Experiment	22190627	MGI
involved in synaptic signaling via neuropeptide	IDA IDA: Inferred from direct assay	22190627	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	22190627	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	22190627	MGI
located in membrane	IDA IDA: Inferred from direct assay	9802393	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	24316073	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	22190627	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy5r Protein Structure

7tmA_NPY5R

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

neuropeptide Y receptor type 5

NPY-Y5 receptor

Y5 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107734	L 152804	Antagonist	99.48%	Unkown
HY-RS09520	NPY5R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09521	Npy5r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09522	Npy5r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npy5r	NCBI	NCBI:4889

Name
Email *

	Sorry, but the email address you supplied was invalid.