Ntrk2 - neurotrophic tyrosine kinase, receptor, type 2 Gene

Mus musculus

Also known as Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB

Gene ID: 18212 | Gene type: protein coding

About Ntrk2

Chromosome 13: 58,954,383-59,281,784 forward strand.GRCm39:CM001006.3

This gene has 10 transcripts (splice variants), 288 orthologues, 53 paralogues and is associated with 103 phenotypes. Biased expression in frontal lobe adult (RPKM 1.3), cortex adult (RPKM 1.2) and 12 other tissues.

Summary

Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk2 Products(3)

mRNA	Protein	Name
NM_008745.3	NP_032771.1	BDNF/NT-3 growth factors receptor isoform b precursor
NM_001025074.2	NP_001020245.1	BDNF/NT-3 growth factors receptor isoform a precursor
NM_001282961.1	NP_001269890.1	BDNF/NT-3 growth factors receptor isoform a precursor

Ntrk2 Protein Structure

LRR_8

TPKR_C2

IgI_TrkB_d5

PTKc_TrkB

0
200
400
600
821 a.a.

Protein Preferred Names

Protein Names

BDNF/NT-3 growth factors receptor

neurotrophic tyrosine receptor kinase type 2

trkB tyrosine kinase

Recombinant Ntrk2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72436	TrkB Protein, Mouse (398a.a, HEK293, His)	P15209-1 (C32-H429)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09631	NTRK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09632	Ntrk2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09633	Ntrk2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk2	NCBI	NCBI:4915
Canis familiaris	Ntrk2	NCBI	NCBI:484147
Rattus norvegicus	Ntrk2	NCBI	NCBI:25054

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