Ntrk2 - neurotrophic receptor tyrosine kinase 2 Gene

Rattus norvegicus

Also known as Tkrb; trkB; TRKB1; trk-B; RATTRKB1

Gene ID: 25054 | Gene type: protein coding

About Ntrk2

Primary_assembly 17: 5,559,043-5,869,136 reverse strand.mRatBN7.2:CM026990.1

This gene has 5 transcripts (splice variants), 288 orthologues, 54 paralogues and is associated with 42 phenotypes. Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues.

Summary

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk2 Products(2)

mRNA	Protein	Name
NM_001163168.3	NP_001156640.1	BDNF/NT-3 growth factors receptor isoform 2 precursor
NM_012731.3	NP_036863.1	BDNF/NT-3 growth factors receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables brain-derived neurotrophic factor binding	IDA IDA: Inferred from direct assay	1645620	RGD
enables brain-derived neurotrophic factor binding	IMP IMP: Inferred from mutant phenotype	16983663	RGD
enables brain-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	1645620	RGD
enables neurotrophin binding	IDA IDA: Inferred from direct assay	1645620	RGD
enables neurotrophin receptor activity	IDA IDA: Inferred from direct assay	16477614	RGD
enables neurotrophin receptor activity	IMP IMP: Inferred from mutant phenotype	16983663	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9582017	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8627351	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16801538	RGD
enables transmembrane receptor protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	17447135	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	1645620	RGD
involved in brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15654844	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	21958434	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	21958434	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21958434	RGD
involved in long-term memory	IDA IDA: Inferred from direct assay	21136519	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10985347	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	10985347	RGD
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	10985347	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9582017	RGD
acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23878391	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	10985347	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	16983663	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9582017	RGD
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	17447135	RGD
involved in regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9582017	RGD
involved in regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	15654844	RGD
involved in regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	16477614	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	21034795	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18322102	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	17640634	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17079678	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	18582438	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17079678	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17079678	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	18582438	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	17079678	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10679783	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25632160	RGD
located in growth cone	IDA IDA: Inferred from direct assay	17079678	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17079678	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16626872	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21775604	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	1645620	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	25632160	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	25632160	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	10679783	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	31784514	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	16477614	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk2 Protein Structure

LRR_8

TPKR_C2

IgI_TrkB_d5

PTKc_TrkB

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

BDNF/NT-3 growth factors receptor

GP145-TrkB/GP95-TrkB	neural receptor protein-tyrosine kinase (trkB)
neurotrophic tyrosine kinase, receptor, type 2	neurotrophic tyrosine receptor kinase type 2
trkB tyrosine kinase

Recombinant Ntrk2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73574	TrkB Protein, Rat (HEK293, His, solution)	Q63604-2 (C32-H429)	≥95%
HY-P73575	TrkB Protein, Rat (HEK293, Fc)	Q63604 (M1-H429)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 3 Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 3
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS09631	NTRK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09632	Ntrk2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09633	Ntrk2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Rare Diseases Unkown
HY-P991098	Anti-TrkB/NTRK2 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk2	NCBI	NCBI:4915
Canis familiaris	Ntrk2	NCBI	NCBI:484147
Mus musculus	Ntrk2	NCBI	NCBI:18212

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