2. Gene
  3. Tnfrsf11b - tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Gene

Tnfrsf11b - tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Opg; TR1; OCIF

Gene ID: 18383 | Gene type: protein coding

About Tnfrsf11b

Summary

Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF Receptor Superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11b Products(2)

mRNA Protein Name
NM_001411506.1 NP_001398435.1 tumor necrosis factor receptor superfamily member 11B isoform 2
NM_008764.4 NP_032790.3 tumor necrosis factor receptor superfamily member 11B isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables heparan sulfate binding IDA
IDA: Inferred from direct assay
29415886 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23039992 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within negative regulation of odontogenesis of dentin-containing tooth IDA
IDA: Inferred from direct assay
14981127 MGI
acts upstream of or within negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
29415886 MGI
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
9168977 MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
29415886 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
9108485 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 11B

osteoclastogenesis inhibitory factor

osteoprotegerin

Recombinant Tnfrsf11b Proteins

Cat. No. Product Name Accession Purity
HY-P71017 TNFRSF11B/OPG Protein, Mouse (HEK293, His) O08712 (E22-L401) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14802 TNFRSF11B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf11b NCBI NCBI:4982
Macaca mulatta Tnfrsf11b NCBI NCBI:701850