P2rx1 - purinergic receptor P2X, ligand-gated ion channel, 1 Gene

Mus musculus

Also known as P2x; RP-2; Pdcd3

Gene ID: 18436 | Gene type: protein coding

About P2rx1

Chromosome 11: 72,889,929-72,906,026 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in bladder adult (RPKM 22.3) and thymus adult (RPKM 21.4).

Summary

Enables cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]

P2rx1 Products(1)

mRNA	Protein	Name
NM_008771.3	NP_032797.3	P2X purinoceptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	10638758	MGI
enables purinergic nucleotide receptor activity	IMP IMP: Inferred from mutant phenotype	10638758	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16325464	MGI
acts upstream of or within ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16325464	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	15914557	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15914557	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	10638758	MGI
acts upstream of or within insemination	IMP IMP: Inferred from mutant phenotype	10638758	MGI
acts upstream of monoatomic ion transport	IGI IGI: Inferred from genetic interaction	15914557	MGI
acts upstream of monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	15914557	MGI
acts upstream of or within monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	10638758	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	12913094	MGI
acts upstream of or within positive regulation of monoatomic ion transport	IGI IGI: Inferred from genetic interaction	15914557	MGI
acts upstream of or within positive regulation of monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	15914557	MGI
acts upstream of or within regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	16920810	MGI
acts upstream of or within regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10638758	MGI
acts upstream of or within regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	16920810	MGI
acts upstream of or within regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	14679185	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	14679185	MGI
acts upstream of or within serotonin secretion by platelet	IMP IMP: Inferred from mutant phenotype	12913094	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11570704	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11668586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx1 Protein Structure

P2X

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 1

ATP receptor	P2X1 receptor
programmed cell death 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09897	P2RX1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09898	P2rx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09899	P2rx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx1	NCBI	NCBI:5023

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