P4hb - prolyl 4-hydroxylase, beta polypeptide Gene

Mus musculus

Also known as PDI; Thbp; ERp59; Pdia1

Gene ID: 18453 | Gene type: protein coding

About P4hb

Summary

Enables Integrin binding activity. Acts upstream of or within cellular response to interleukin-7. Located in endoplasmic reticulum and external side of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

P4hb Products(1)

mRNA	Protein	Name
NM_011032.3	NP_035162.1	protein disulfide-isomerase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	21670307	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21670307	MGI
enables protein-disulfide reductase activity	IMP IMP: Inferred from mutant phenotype	31184304	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to interleukin-7	IDA IDA: Inferred from direct assay	29581031	MGI
acts upstream of positive effect endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	31184304	MGI
involved in insulin processing	IMP IMP: Inferred from mutant phenotype	31184304	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9493907	MGI
part of endoplasmic reticulum chaperone complex	IDA IDA: Inferred from direct assay	12475965	MGI
is active in endoplasmic reticulum lumen	IMP IMP: Inferred from mutant phenotype	31184304	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	21670307	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein disulfide-isomerase

ER protein 59	cellular thyroid hormone-binding protein
endoplasmic reticulum resident protein 59	p55
prolyl 4-hydroxylase subunit beta

Recombinant P4hb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74658	P4HB Protein, Mouse (HEK293, His)	P09103 (D20-L509)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09945	P4HB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P4hb	NCBI	NCBI:5034

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