2. Gene
  3. Pecam1 - platelet/endothelial cell adhesion molecule 1 Gene

Pecam1 - platelet/endothelial cell adhesion molecule 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cd31; Pecam; PECAM-1

Gene ID: 18613 | Gene type: protein coding

About Pecam1

Summary

Predicted to enable protein homodimerization activity; protein Phosphatase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including Rho protein signal transduction; endothelial cell morphogenesis; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including cell-cell contact zone; external side of plasma membrane; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease (multiple); lung non-small cell carcinoma; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Pecam1 Products(4)

mRNA Protein Name
NM_001032378.2 NP_001027550.1 platelet endothelial cell adhesion molecule isoform 2 precursor
NM_001305157.1 NP_001292086.1 platelet endothelial cell adhesion molecule isoform 3 precursor
NM_001305158.1 NP_001292087.1 platelet endothelial cell adhesion molecule isoform 4 precursor
NM_008816.3 NP_032842.2 platelet endothelial cell adhesion molecule isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10562326 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
12890700 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
17563397 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
20724702 MGI
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
17563397 MGI
acts upstream of or within endothelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
17563397 MGI
acts upstream of or within endothelial cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
17563397 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
11254359 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
12890700 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
12890700 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell periphery IDA
IDA: Inferred from direct assay
21464233 MGI
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
20724702 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20724702 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16455951 MGI
located in membrane IDA
IDA: Inferred from direct assay
16691571 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
12890700 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12736726 MGI
located in smooth muscle contractile fiber IDA
IDA: Inferred from direct assay
18332105 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet endothelial cell adhesion molecule

Recombinant Pecam1 Proteins

Cat. No. Product Name Accession Purity
HY-P72737 CD31/PECAM-1 Protein, Mouse (HEK293, His) Q08481 (E18-K590) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3444 CD31 / Unkown
HY-P3444A CD31 TFA / Unkown
HY-RS10315 PECAM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pecam1 NCBI NCBI:5175