E2F5 - E2F transcription factor 5 Gene

Homo sapiens

Also known as E2F-5

Gene ID: 1875 | Gene type: protein coding

About E2F5

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,177,154-85,214,518 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 7 paralogues. Broad expression in lymph node (RPKM 12.6), thyroid (RPKM 6.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

E2F5 Products(3)

mRNA	Protein	Name
NM_001083588.2	NP_001077057.1	transcription factor E2F5 isoform 2
NM_001083589.2	NP_001077058.1	transcription factor E2F5 isoform 3
NM_001951.4	NP_001942.2	transcription factor E2F5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	17062573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12502741	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F5 Protein Structure

E2F_TDP

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

transcription factor E2F5

E2F transcription factor 5, p130-binding

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04114	E2F5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	E2F5	MGD	MGI:105091
Macaca mulatta	E2F5	VGNC	VGNC:72026
Canis familiaris	E2F5	VGNC	VGNC:40167
Felis catus	E2F5	VGNC	VGNC:81648
Bos taurus	E2F5	VGNC	VGNC:28289
Rattus norvegicus	E2F5	RGD	RGD:621357

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