Prkca - protein kinase C, alpha Gene

Mus musculus

Also known as Pkca

Gene ID: 18750 | Gene type: protein coding

About Prkca

Chromosome 11: 107,824,213-108,234,754 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 8 phenotypes. Broad expression in frontal lobe adult (RPKM 19.9), cortex adult (RPKM 11.1) and 22 other tissues.

Summary

Enables calcium-dependent protein kinase C activity and Integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including calyx of Held; intercalated disc; and photoreceptor outer segment. Part of alphav-beta3 integrin-PKCalpha complex. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca Products(1)

mRNA	Protein	Name
NM_011101.3	NP_035231.2	protein kinase C alpha type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	7741753	MGI
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	7828597	MGI
enables diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12618484	MGI
enables integrin binding	IPI IPI: Inferred from physical interaction	16014375	MGI
enables lipid binding	EXP EXP: Inferred from Experiment	23762412	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12618484	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14966518	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	17956267	MGI
acts upstream of or within cellular response to carbohydrate stimulus	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: Inferred from direct assay	17644814	MGI
acts upstream of or within induction of positive chemotaxis	IMP IMP: Inferred from mutant phenotype	12928424	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	12928424	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within negative regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	11923480	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11923480	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17956267	MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11923480	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	11923480	MGI
acts upstream of or within negative regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24305805	MGI
acts upstream of or within negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	12928424	MGI
acts upstream of or within peptidyl-serine autophosphorylation	IDA IDA: Inferred from direct assay	16814779	MGI
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	16014375	MGI
involved in positive regulation of dense core granule biogenesis	IMP IMP: Inferred from mutant phenotype	19147982	MGI
acts upstream of or within positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	12928424	MGI
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	9508782	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14966518	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	21658591	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21658591	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	7741753	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	31578312	MGI
acts upstream of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24305805	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within regulation of muscle contraction	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	11940581	MGI
involved in regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	19147982	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	21658591	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	21658591	MGI
acts upstream of or within regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	14966518	MGI
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	17644814	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of alphav-beta3 integrin-PKCalpha complex	IDA IDA: Inferred from direct assay	16014375	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	23863479	MGI
located in axon	IDA IDA: Inferred from direct assay	18265009	MGI
is active in calyx of Held	IDA IDA: Inferred from direct assay	21658591	MGI
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	21658591	MGI
located in cone photoreceptor outer segment	IDA IDA: Inferred from direct assay	10813773	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10882525	MGI
located in dendrite	IDA IDA: Inferred from direct assay	12115694	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	27353086	MGI
located in membrane	IDA IDA: Inferred from direct assay	18323529	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12826667	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	12115694	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10882525	MGI
located in ooplasm	IDA IDA: Inferred from direct assay	15590069	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10882525	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	21658591	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27353086	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkca Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

STKc_cPKC_alpha

0
200
400
600
672 a.a.

Protein Preferred Names

Protein Names

protein kinase C alpha type

PKC-A	PKC-alpha
protein kinase c-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11116	PRKCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11117	Prkca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11118	Prkca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkca	NCBI	NCBI:5578

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