Prkcb - protein kinase C, beta Gene

Mus musculus

Also known as Pkcb; PKC-B; Prkcb1; Prkcb2; PKC-Beta

Gene ID: 18751 | Gene type: protein coding

About Prkcb

Chromosome 7: 121,887,974-122,233,625 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in cortex adult (RPKM 62.), frontal lobe adult (RPKM 44.4) and 8 other tissues.

Summary

Enables Calcium Channel regulator activity and protein kinase C activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; and response to hypoxia. Located in cytoplasm; membrane; and nucleus. Part of spectrin. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; retina; and salivary gland. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb Products(2)

mRNA	Protein	Name
NM_001316672.1	NP_001303601.1	protein kinase C beta type isoform 2
NM_008855.2	NP_032881.1	protein kinase C beta type isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	11880265	MGI
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	27226533	MGI
enables diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12618484	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15188402	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23775122	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell activation	IMP IMP: Inferred from mutant phenotype	12118249	MGI
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12118249	MGI
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	11880265	MGI
acts upstream of or within cellular response to carbohydrate stimulus	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	11880265	MGI
involved in negative regulation of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	10499500	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	27226533	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	11805327	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12118249	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	27226533	MGI
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11805327	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	21658591	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21658591	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12618484	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	21658591	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	21658591	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	21658591	MGI
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	21658591	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12826667	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14613966	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	27226533	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	21658591	MGI
part of spectrin	IDA IDA: Inferred from direct assay	10534118	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcb Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

STKc_cPKC_beta

0
200
400
600
673 a.a.

Protein Preferred Names

Protein Names

protein kinase C beta type

protein kinase C beta-II

protein kinase C, beta 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11119	PRKCB Human Pre-designed siRNA Set A	/	Unkown
HY-RS11120	Prkcb Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11121	Prkcb Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcb	NCBI	NCBI:5579

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