Prkcg - protein kinase C, gamma Gene

Mus musculus

Also known as Pkcc; Prkcc; PKCgamma

Gene ID: 18752 | Gene type: protein coding

About Prkcg

Chromosome 7: 3,337,704-3,379,615 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 201 orthologues, 9 paralogues and is associated with 13 phenotypes. Biased expression in cerebellum adult (RPKM 34.3), frontal lobe adult (RPKM 31.8) and 5 other tissues.

Summary

Predicted to enable calcium-dependent protein kinase C activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cellular protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior and regulation of phagocytosis. Located in several cellular components, including calyx of Held; postsynaptic density; and synaptic membrane. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]

Prkcg Products(2)

mRNA	Protein	Name
NM_001291434.1	NP_001278363.1	protein kinase C gamma type isoform 2
NM_011102.4	NP_035232.1	protein kinase C gamma type isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23115168	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23185022	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	8548809	MGI
acts upstream of or within chemosensory behavior	IMP IMP: Inferred from mutant phenotype	11606660	MGI
involved in innervation	IMP IMP: Inferred from mutant phenotype	8548809	MGI
involved in negative regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	23185022	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	23185022	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23115168	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24794094	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24794094	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23185022	MGI
acts upstream of or within regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	15006698	MGI
involved in regulation of response to food	IMP IMP: Inferred from mutant phenotype	23185022	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	24794094	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	24794094	MGI
involved in response to morphine	IMP IMP: Inferred from mutant phenotype	11246146	MGI
involved in response to pain	IMP IMP: Inferred from mutant phenotype	9323205	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	24794094	MGI
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	24794094	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10882525	MGI
located in dendrite	IDA IDA: Inferred from direct assay	11549583	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10882525	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10882525	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	24794094	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	18473171	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcg Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

STKc_cPKC

0
200
400
600
697 a.a.

Protein Preferred Names

Protein Names

protein kinase C gamma type

PKC-gamma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases Unkown
HY-RS11128	PRKCG Human Pre-designed siRNA Set A	/	Unkown
HY-RS11129	Prkcg Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11130	Prkcg Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcg	NCBI	NCBI:5582

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