Prkce - protein kinase C, epsilon Gene

Mus musculus

Also known as Pkce; PKC[e]; PKCepsilon; 5830406C15Rik

Gene ID: 18754 | Gene type: protein coding

About Prkce

Chromosome 17: 86,475,213-86,965,347 forward strand.GRCm39:CM001010.3

This gene has 5 transcripts (splice variants), 312 orthologues, 9 paralogues and is associated with 15 phenotypes. Broad expression in frontal lobe adult (RPKM 22.3), cortex adult (RPKM 2.6) and 19 other tissues.

Summary

Enables several functions, including 14-3-3 protein binding activity; actin monomer binding activity; and calcium-independent protein kinase C activity. Involved in several processes, including TRAM-dependent Toll-like Receptor 4 signaling pathway; positive regulation of actin filament polymerization; and positive regulation of fibroblast migration. Acts upstream of or within several processes, including cellular response to alcohol; positive regulation of cell communication; and regulation of secretion. Located in several cellular components, including cytosol; mitochondrion; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; neural retina; and salivary gland. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Prkce Products(1)

mRNA	Protein	Name
NM_011104.3	NP_035234.1	protein kinase C epsilon type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	18604201	MGI
enables actin monomer binding	IDA IDA: Inferred from direct assay	11746497	MGI
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10879655	MGI
enables ethanol binding	IDA IDA: Inferred from direct assay	19432558	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11139474	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17875639	MGI
enables signaling receptor activator activity	IDA IDA: Inferred from direct assay	17875639	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IDA IDA: Inferred from direct assay	11884367	MGI
involved in TRAM-dependent toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	16757566	MGI
acts upstream of cell-substrate adhesion	IGI IGI: Inferred from genetic interaction	15949469	MGI
acts upstream of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	15949469	MGI
acts upstream of or within cellular response to ethanol	IGI IGI: Inferred from genetic interaction	17875639	MGI
acts upstream of or within cellular response to hypoxia	IDA IDA: Inferred from direct assay	18070622	MGI
acts upstream of or within cellular response to prostaglandin E stimulus	IDA IDA: Inferred from direct assay	23479225	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12837755	MGI
acts upstream of insulin secretion	IMP IMP: Inferred from mutant phenotype	12837755	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11696589	MGI
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16757566	MGI
acts upstream of or within locomotory exploration behavior	IGI IGI: Inferred from genetic interaction	17908177	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	11696589	MGI
acts upstream of mucus secretion	IMP IMP: Inferred from mutant phenotype	17728398	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	25470454	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11884367	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11696589	MGI
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	11746497	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	11696589	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IGI IGI: Inferred from genetic interaction	15949469	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	15949469	MGI
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	16270034	MGI
acts upstream of or within positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	12837755	MGI
acts upstream of or within positive regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19401415	MGI
acts upstream of or within positive regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	17728398	MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17875639	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12551921	MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19401415	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	19401415	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	11940581	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	23479225	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	15905535	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	16899053	MGI
acts upstream of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17875639	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	17611075	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	17611075	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14613966	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11884367	MGI
located in membrane	IDA IDA: Inferred from direct assay	16270034	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11884367	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14613966	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17611075	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkce Protein Structure

C2_PKC_epsilon

C1_nPKC_epsilon-like_rpt1

C1_nPKC_epsilon-like_rpt2

STKc_nPKC_epsilon

0
200
400
600
737 a.a.

Protein Preferred Names

Protein Names

protein kinase C epsilon type

PCK epsilon

nPKC-epsilon

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1803	Protein Kinase C Peptide Substrate		/	Unkown
HY-RS11125	PRKCE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11126	Prkce Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11127	Prkce Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkce	NCBI	NCBI:5581

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