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  2. Prkch - protein kinase C, eta Gene

Prkch - protein kinase C, eta Gene

Mus musculus

Also known as Pkch

Gene ID: 18755 | Gene type: protein coding

About Prkch

Chromosome 12: 73,631,570-73,824,959 forward strand.GRCm39:CM001005.3

This gene has 4 transcripts (splice variants), 241 orthologues, 9 paralogues and is associated with 33 phenotypes. Broad expression in lung adult (RPKM 17.2), thymus adult (RPKM 13.2) and 21 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Prkch Products(2)

mRNA Protein Name
NM_008856.4 NP_032882.2 protein kinase C eta type isoform 1
NM_001313977.1 NP_001300906.1 protein kinase C eta type isoform 2

Prkch Protein Structure

C2_PKC_epsilon

C2_PKC_epsilon: cd04014 (7 - 139)

C1_nPKC_epsilon-like_rpt1

C1_nPKC_epsilon-like_rpt1: cd20835 (165 - 225)

C1_nPKC_epsilon-like_rpt2

C1_nPKC_epsilon-like_rpt2: cd20838 (243 - 297)

STKc_nPKC_eta

STKc_nPKC_eta: cd05590 (358 - 680)

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  • 683 a.a.
Protein Preferred Names Protein Names

protein kinase C eta type

PKC-L

nPKC-eta

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkch NCBI NCBI:5583