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  2. Prkcz - protein kinase C, zeta Gene

Prkcz - protein kinase C, zeta Gene

Mus musculus

Also known as Pkcz; zetaPKC; aPKCzeta; nPKC-zeta

Gene ID: 18762 | Gene type: protein coding

About Prkcz

Chromosome 4: 155,344,586-155,445,818 reverse strand.GRCm39:CM000997.3

This gene has 10 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 22 phenotypes. Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz Products(3)

mRNA Protein Name
NM_001355178.1 NP_001342107.1 protein kinase C zeta type isoform c
NM_008860.3 NP_032886.2 protein kinase C zeta type isoform a
NM_001039079.2 NP_001034168.1 protein kinase C zeta type isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16792529 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14730360 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21131967 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
19668197 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15882626 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
19668197 MGI
involved in positive regulation of T-helper 2 cell cytokine production IMP
IMP: Inferred from mutant phenotype
15987782 MGI
involved in positive regulation of T-helper 2 cell differentiation IMP
IMP: Inferred from mutant phenotype
15987782 MGI
involved in positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
15987782 MGI
involved in positive regulation of interleukin-13 production IMP
IMP: Inferred from mutant phenotype
15987782 MGI
involved in positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
15987782 MGI
involved in positive regulation of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
15987782 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
16455755 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
14730360 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical cortex IDA
IDA: Inferred from direct assay
15950600 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20551175 MGI
located in axon hillock IDA
IDA: Inferred from direct assay
19668197 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
15775979 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
15950600 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10882525 MGI
located in microtubule organizing center IGI
IGI: Inferred from genetic interaction
19668197 MGI
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
20237282 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
10882525 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
10882525 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10882525 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10882525 MGI
located in vesicle IDA
IDA: Inferred from direct assay
17313651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcz Protein Structure

PB1_aPKC

PB1_aPKC: cd06404 (15 - 97)

C1

C1: cl00040 (128 - 182)

PKc_like

PKc_like: cl21453 (235 - 591)

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  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

protein kinase C zeta type

atypical protein kinase C

protein kinase C zeta subspecies

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcz NCBI NCBI:5590