PRKCZ - protein kinase C zeta Gene

Homo sapiens

Also known as PKC2; PKC-ZETA

Gene ID: 5590 | Gene type: protein coding

About PRKCZ

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:2,048,504-2,185,395 (from NCBI)

This gene has 26 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues.

Summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from Other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKCZ Products(35)

mRNA	Protein	Name
NR_146911.2
XM_017001789.2	XP_016857278.1	protein kinase C zeta type isoform X1
XM_024448396.2	XP_024304164.1	protein kinase C zeta type isoform X14
XM_011541776.2	XP_011540078.1	protein kinase C zeta type isoform X14
XR_007061965.1
XR_007061966.1
XM_017001803.3	XP_016857292.1	protein kinase C zeta type isoform X18
XM_024448397.2	XP_024304165.1	protein kinase C zeta type isoform X16
NM_001350805.2	NP_001337734.1	protein kinase C zeta type isoform 5
XM_017001793.2	XP_016857282.1	protein kinase C zeta type isoform X10
XM_047425273.1	XP_047281229.1	protein kinase C zeta type isoform X7
XM_047425260.1	XP_047281216.1	protein kinase C zeta type isoform X5
XM_047425262.1	XP_047281218.1	protein kinase C zeta type isoform X6
XM_011541775.4	XP_011540077.1	protein kinase C zeta type isoform X13
XM_047425304.1	XP_047281260.1	protein kinase C zeta type isoform X10
XM_017001802.2	XP_016857291.1	protein kinase C zeta type isoform X17
NM_001242874.3	NP_001229803.1	protein kinase C zeta type isoform 3
XM_017001797.2	XP_016857286.1	protein kinase C zeta type isoform X12
XM_047425348.1	XP_047281304.1	protein kinase C zeta type isoform X15
NM_001350803.2	NP_001337732.1	protein kinase C zeta type isoform 4
XM_047425323.1	XP_047281279.1	protein kinase C zeta type isoform X11
XM_024448391.2	XP_024304159.1	protein kinase C zeta type isoform X10
XM_017001792.2	XP_016857281.1	protein kinase C zeta type isoform X10
XM_017001790.2	XP_016857279.1	protein kinase C zeta type isoform X2
XM_047425307.1	XP_047281263.1	protein kinase C zeta type isoform X10
XM_011541773.2	XP_011540075.1	protein kinase C zeta type isoform X3
XM_047425340.1	XP_047281296.1	protein kinase C zeta type isoform X14
XM_047425255.1	XP_047281211.1	protein kinase C zeta type isoform X4
XM_011541774.2	XP_011540076.1	protein kinase C zeta type isoform X8
XM_047425283.1	XP_047281239.1	protein kinase C zeta type isoform X9
NM_001033581.3	NP_001028753.1	protein kinase C zeta type isoform 2
NM_001350806.2	NP_001337735.1	protein kinase C zeta type isoform 5
NM_001033582.3	NP_001028754.1	protein kinase C zeta type isoform 2
NM_002744.6	NP_002735.3	protein kinase C zeta type isoform 1
NM_001350804.2	NP_001337733.1	protein kinase C zeta type isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12391145	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10831594	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	10770950	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15069075	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15069075	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15069075	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	15069075	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15069075	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11035106	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10770950	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	20332120	GOA
located in vesicle	IDA IDA: Inferred from direct assay	17313651	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCZ Protein Structure

PB1

C1_1

Pkinase

Pkinase_C

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

protein kinase C zeta type

nPKC-zeta

PRKCZ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKCZ	Q05513	AGER	Homo sapiens	Q15109	Anti Bait CoIP	21829704
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	33961781
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	Anti Bait CoIP	24375676
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	CoIP	11260256
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	28514442
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	Pull Down	32707033
Intra	PRKCZ	Q05513	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	25852190
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Pull Down	32707033
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	CoIP	11260256
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	27107012
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	31980649
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	BFG-2H	27107012
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	PRKCZ	Q05513	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	25852190
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	17057644
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	31980649
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	25852190
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	33961781
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Pull Down	32707033
Intra	PRKCZ	Q05513	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	28514442
Intra	PRKCZ	Q05513	AKT1	Homo sapiens	P31749	Anti Bait CoIP	18650932
Intra	PRKCZ	Q05513	VHL	Homo sapiens	P40337	Anti Tag CoIP	17350623
Intra	PRKCZ	Q05513	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	25852190
Intra	PRKCZ	Q05513	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	31980649
Intra	PRKCZ	Q05513	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKCZ	Q05513	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	PRKCZ	Q05513	PRKCQ	Homo sapiens	Q04759	Anti Bait CoIP	17588663
Intra	PRKCZ	Q05513	PRKCQ	Homo sapiens	Q04759	Protein Kinase Assay	17588663
Intra	PRKCZ	Q05513	NCF1	Homo sapiens	P14598	Pull Down	27040869
Intra	PRKCZ	Q05513	NCF1	Homo sapiens	P14598	Anti Bait CoIP	27040869
Intra	PRKCZ	Q05513	NUMB	Homo sapiens	P49757-1	Anti Tag CoIP	17203073
Intra	PRKCZ	Q05513	NUMB	Homo sapiens	P49757-1	Pull Down	17203073
Intra	PRKCZ	Q05513	NUMB	Homo sapiens	P49757-1	Protein Kinase Assay	17203073
Intra	PRKCZ	Q05513	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	17057644
Intra	PRKCZ	Q05513	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
Intra	PRKCZ	Q05513	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	25852190
Intra	PRKCZ	Q05513	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	33961781
Intra	PRKCZ	Q05513	PARD6A	Homo sapiens	Q9NPB6	Y2H Pooling	16189514
Intra	PRKCZ	Q05513	BCL10	Homo sapiens	O95999	Anti Bait CoIP	25011391
Intra	PRKCZ	Q05513	BCL10	Homo sapiens	O95999	PLA	25011391
Intra	PRKCZ	Q05513	BCL10	Homo sapiens	O95999	Confocal	25011391
Cross	PRKCZ	Q05513	numb	Drosophila melanogaster	P16554	Protein Kinase Assay	17203073

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diabetes Mellitus

Diabetes

Combined Oxidative Phosphorylation Deficiency 33

COXPD33

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11141	PRKCZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11142	Prkcz Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11143	Prkcz Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKCZ	VGNC	VGNC:33336
Felis catus	PRKCZ	VGNC	VGNC:80323
Mus musculus	PRKCZ	MGD	MGI:97602
Macaca mulatta	PRKCZ	VGNC	VGNC:82212
Rattus norvegicus	PRKCZ	RGD	RGD:3399
Canis familiaris	PRKCZ	VGNC	VGNC:44985
Others	PRKCZ	NCBI

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