Pla2g2a - phospholipase A2, group IIA (platelets, synovial fluid) Gene

Mus musculus

Also known as EF; Mom1; Pla2; sPLA2; sPla2-IIA

Gene ID: 18780 | Gene type: protein coding

About Pla2g2a

Summary

Proteins belonging to the Phospholipase A2 (PLA2) family hydrolyze Phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of Phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted Enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in Other strains. [provided by RefSeq, Jul 2008]

Pla2g2a Products(1)

mRNA	Protein	Name
NM_001082531.1	NP_001076000.1	phospholipase A2, membrane associated precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10451698	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	10358193	MGI
involved in intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	27292189	MGI
NOT acts upstream of or within negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19564598	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10451698	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	9288104	MGI
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	27292189	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10716720	MGI
acts upstream of or within regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	9159163	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	8978062	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	1541640	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipase A2, membrane associated

GIIC sPLA2	enhancing factor
group IIA phospholipase A2	modifier of Min1
non-pancreatic secreted type II phospholipase A2	phosphatidylcholine 2-acylhydrolase 2A
secretory group II phospholipase A2

Recombinant Pla2g2a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74628	PLA2G2A Protein, Mouse (P.pastoris, His)	P31482 (N22-C146)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10621	PLA2G2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g2a	NCBI	NCBI:5320

Name
Email *

	Sorry, but the email address you supplied was invalid.