Ppard - peroxisome proliferator activator receptor delta Gene

Mus musculus

Also known as NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta

Gene ID: 19015 | Gene type: protein coding

About Ppard

Chromosome 17: 28,451,674-28,520,448 forward strand.GRCm39:CM001010.3

This gene has 9 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 77 phenotypes. Broad expression in duodenum adult (RPKM 12.2), colon adult (RPKM 88.9) and 16 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard Products(7)

mRNA	Protein	Name
NM_001411522.1	NP_001398451.1	peroxisome proliferator-activated receptor delta isoform 5
NM_001411526.1	NP_001398455.1	peroxisome proliferator-activated receptor delta isoform 1
NM_001411510.1	NP_001398439.1	peroxisome proliferator-activated receptor delta isoform 1
NM_001411509.1	NP_001398438.1	peroxisome proliferator-activated receptor delta isoform 2
NM_011145.4	NP_035275.1	peroxisome proliferator-activated receptor delta isoform 1
NM_001411521.1	NP_001398450.1	peroxisome proliferator-activated receptor delta isoform 4
NM_001411520.1	NP_001398449.1	peroxisome proliferator-activated receptor delta isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8041794	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20445066	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10385625	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	11756685	MGI
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	15713628	MGI
acts upstream of or within axon ensheathment	IMP IMP: Inferred from mutant phenotype	10866668	MGI
acts upstream of or within cell differentiation	IDA IDA: Inferred from direct assay	16581799	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	16581799	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11756685	MGI
acts upstream of or within cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	11514592	MGI
acts upstream of or within cellular response to hypoxia	IGI IGI: Inferred from genetic interaction	24011070	MGI
acts upstream of or within embryo implantation	IDA IDA: Inferred from direct assay	10385625	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	19345188	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	11756685	MGI
acts upstream of fat cell proliferation	IMP IMP: Inferred from mutant phenotype	11756685	MGI
involved in fatty acid beta-oxidation	IEP IEP: Inferred from expression pattern	14676330	MGI
involved in fatty acid transport	IEP IEP: Inferred from expression pattern	14676330	MGI
acts upstream of or within keratinocyte migration	IMP IMP: Inferred from mutant phenotype	11514592	MGI
acts upstream of or within keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	11511099	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	10866668	MGI
NOT acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	11756685	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	14758356	MGI
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	20445066	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	22040534	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8041794	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16581799	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	11756685	MGI
acts upstream of or within positive regulation of fat cell proliferation	IMP IMP: Inferred from mutant phenotype	11756685	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22040534	MGI
involved in positive regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	22040534	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16581799	MGI
involved in positive regulation of skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	22040534	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15380519	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10866668	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	11756685	MGI
involved in regulation of skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	22040534	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	11514592	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20445066	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10385625	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppard Protein Structure

NR_DBD_Ppar

NR_LBD_PPAR

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

peroxisome proliferator-activated receptor delta

PPARdelta/beta	Peroxisome proliferator-activated receptor beta
nuclear hormone receptor 1	nuclear receptor subfamily 1 group C member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121579	L-764406	Agonist	/	Unkown
HY-RS10922	PPARD Human Pre-designed siRNA Set A		/	Unkown
HY-RS10923	Ppard Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10924	Ppard Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppard	NCBI	NCBI:5467

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