2. Gene
  3. LPAR1 - lysophosphatidic acid receptor 1 Gene

LPAR1 - lysophosphatidic acid receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EDG2; LPA1; VZG1; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3

Gene ID: 1902 | Gene type: protein coding

About LPAR1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,873,263-111,038,998 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 8.1) and 22 other tissues.

Summary

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

LPAR1 Products(77)

mRNA Protein Name
NM_001351404.2 NP_001338333.1 lysophosphatidic acid receptor 1 isoform a
NM_001387507.1 NP_001374436.1 lysophosphatidic acid receptor 1 isoform a
NM_001351420.2 NP_001338349.1 lysophosphatidic acid receptor 1 isoform a
NM_001351419.2 NP_001338348.1 lysophosphatidic acid receptor 1 isoform a
NM_001387475.1 NP_001374404.1 lysophosphatidic acid receptor 1 isoform a
NM_001387479.1 NP_001374408.1 lysophosphatidic acid receptor 1 isoform a
NM_001387489.1 NP_001374418.1 lysophosphatidic acid receptor 1 isoform a
NM_001387472.1 NP_001374401.1 lysophosphatidic acid receptor 1 isoform a
NM_001387511.1 NP_001374440.1 lysophosphatidic acid receptor 1 isoform a
NM_001351406.2 NP_001338335.1 lysophosphatidic acid receptor 1 isoform a
NM_001387496.1 NP_001374425.1 lysophosphatidic acid receptor 1 isoform a
NM_001351402.2 NP_001338331.1 lysophosphatidic acid receptor 1 isoform a
NM_001387486.1 NP_001374415.1 lysophosphatidic acid receptor 1 isoform a
NM_001351412.2 NP_001338341.1 lysophosphatidic acid receptor 1 isoform a
NM_001387505.1 NP_001374434.1 lysophosphatidic acid receptor 1 isoform a
NM_001387504.1 NP_001374433.1 lysophosphatidic acid receptor 1 isoform a
NM_001351400.2 NP_001338329.1 lysophosphatidic acid receptor 1 isoform a
NM_001351408.2 NP_001338337.1 lysophosphatidic acid receptor 1 isoform a
NM_001351418.2 NP_001338347.1 lysophosphatidic acid receptor 1 isoform a
NM_001387488.1 NP_001374417.1 lysophosphatidic acid receptor 1 isoform a
NM_001387493.1 NP_001374422.1 lysophosphatidic acid receptor 1 isoform a
NM_001387473.1 NP_001374402.1 lysophosphatidic acid receptor 1 isoform a
NM_001387498.1 NP_001374427.1 lysophosphatidic acid receptor 1 isoform a
NM_001387514.1 NP_001374443.1 lysophosphatidic acid receptor 1 isoform a
NM_001387490.1 NP_001374419.1 lysophosphatidic acid receptor 1 isoform a
NM_001387521.1 NP_001374450.1 lysophosphatidic acid receptor 1 isoform c
XM_047422903.1 XP_047278859.1 lysophosphatidic acid receptor 1 isoform X1
NM_001387471.1 NP_001374400.1 lysophosphatidic acid receptor 1 isoform a
NM_001351411.2 NP_001338340.1 lysophosphatidic acid receptor 1 isoform a
NM_001387487.1 NP_001374416.1 lysophosphatidic acid receptor 1 isoform a
NM_001387480.1 NP_001374409.1 lysophosphatidic acid receptor 1 isoform a
NM_001387501.1 NP_001374430.1 lysophosphatidic acid receptor 1 isoform a
NM_001387492.1 NP_001374421.1 lysophosphatidic acid receptor 1 isoform a
NM_001351401.2 NP_001338330.1 lysophosphatidic acid receptor 1 isoform a
NM_001387481.1 NP_001374410.1 lysophosphatidic acid receptor 1 isoform a
NM_057159.4 NP_476500.1 lysophosphatidic acid receptor 1 isoform a
NM_001387484.1 NP_001374413.1 lysophosphatidic acid receptor 1 isoform a
NM_001387482.1 NP_001374411.1 lysophosphatidic acid receptor 1 isoform a
NM_001351416.2 NP_001338345.1 lysophosphatidic acid receptor 1 isoform a
NM_001351403.2 NP_001338332.1 lysophosphatidic acid receptor 1 isoform a
NM_001387513.1 NP_001374442.1 lysophosphatidic acid receptor 1 isoform a
NM_001351415.2 NP_001338344.1 lysophosphatidic acid receptor 1 isoform a
NM_001387478.1 NP_001374407.1 lysophosphatidic acid receptor 1 isoform a
NM_001387519.1 NP_001374448.1 lysophosphatidic acid receptor 1 isoform c
NM_001387508.1 NP_001374437.1 lysophosphatidic acid receptor 1 isoform a
NM_001351405.2 NP_001338334.1 lysophosphatidic acid receptor 1 isoform a
NM_001387483.1 NP_001374412.1 lysophosphatidic acid receptor 1 isoform a
NM_001387517.1 NP_001374446.1 lysophosphatidic acid receptor 1 isoform b
NM_001351417.2 NP_001338346.1 lysophosphatidic acid receptor 1 isoform a
NM_001351397.2 NP_001338326.1 lysophosphatidic acid receptor 1 isoform a
NM_001387506.1 NP_001374435.1 lysophosphatidic acid receptor 1 isoform a
NM_001387512.1 NP_001374441.1 lysophosphatidic acid receptor 1 isoform a
NM_001387470.1 NP_001374399.1 lysophosphatidic acid receptor 1 isoform a
NM_001351407.2 NP_001338336.1 lysophosphatidic acid receptor 1 isoform a
NM_001387510.1 NP_001374439.1 lysophosphatidic acid receptor 1 isoform a
NM_001387516.1 NP_001374445.1 lysophosphatidic acid receptor 1 isoform b
NM_001387497.1 NP_001374426.1 lysophosphatidic acid receptor 1 isoform a
NM_001351413.2 NP_001338342.1 lysophosphatidic acid receptor 1 isoform a
NM_001351409.2 NP_001338338.1 lysophosphatidic acid receptor 1 isoform a
NM_001351399.2 NP_001338328.1 lysophosphatidic acid receptor 1 isoform a
NM_001387494.1 NP_001374423.1 lysophosphatidic acid receptor 1 isoform a
NM_001387515.1 NP_001374444.1 lysophosphatidic acid receptor 1 isoform a
NM_001351414.2 NP_001338343.1 lysophosphatidic acid receptor 1 isoform a
NM_001401.5 NP_001392.2 lysophosphatidic acid receptor 1 isoform a
NM_001387476.1 NP_001374405.1 lysophosphatidic acid receptor 1 isoform a
NM_001387477.1 NP_001374406.1 lysophosphatidic acid receptor 1 isoform a
NM_001387485.1 NP_001374414.1 lysophosphatidic acid receptor 1 isoform a
NM_001387491.1 NP_001374420.1 lysophosphatidic acid receptor 1 isoform a
NM_001387495.1 NP_001374424.1 lysophosphatidic acid receptor 1 isoform a
NM_001387518.1 NP_001374447.1 lysophosphatidic acid receptor 1 isoform b
NM_001387474.1 NP_001374403.1 lysophosphatidic acid receptor 1 isoform a
NM_001387503.1 NP_001374432.1 lysophosphatidic acid receptor 1 isoform a
NM_001387502.1 NP_001374431.1 lysophosphatidic acid receptor 1 isoform a
NM_001351398.2 NP_001338327.1 lysophosphatidic acid receptor 1 isoform a
NM_001387520.1 NP_001374449.1 lysophosphatidic acid receptor 1 isoform c
NM_001351410.2 NP_001338339.1 lysophosphatidic acid receptor 1 isoform a
NM_001387509.1 NP_001374438.1 lysophosphatidic acid receptor 1 isoform a

LPAR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (67 - 311)

  • 0
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  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 1

LPA receptor 1

LPA-1

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2

lysophosphatidic acid receptor Edg-2

ventricular zone gene 1

Related Diseases

Diseases Alias
Spinal Stenosis

Lumbar Spinal Stenosis

Cervical Spinal Stenosis

Spinal Stenosis Of Lumbar Region

Spinal Stenosis In Cervical Region

Spinal Canal Stenosis
Hypotrichosis 8

HYPT8

Lah3

Hypotrichosis, Localized, Autosomal Recessive 3

Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis

Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis

Hypotrichosis Localized Autosomal Recessive 3

Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis

ARWH1

Hypotrichosis, Type 8
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction

Chronic Intestinal Pseudo-Obstruction

Cipo

Neuronal Intestinal Dysplasia

Hollow Visceral Myopathy

Familial Visceral Neuropathy

Paralytic Ileus

Intestinal Pseudoobstruction

Chronic Idiopathic Intestinal Pseudo-Obstruction

Ciip

Congenital Short Bowel Syndrome

Enteric Neuropathy

Familial Visceral Myopathy

Ipo

Pseudo-Obstruction Of Intestine

Pseudointestinal Obstruction Syndrome

Pseudoobstructive Syndrome

Congenital Idiopathic Intestinal Pseudoobstruction

Visceral Myopathy, Familial
Pulmonary Fibrosis

Fibrosis Of Lung
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Fibrosclerosis Of Breast

Fibrosis Of The Breast

Breast Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16039 AM095 Antagonist 99.72% Unkown
HY-15706 H2L 5765834 Antagonist 98.36% Unkown
HY-117444 ONO-9780307 Inhibitor 99.94% Unkown
HY-117959 TAK-615 Inhibitor 98.97% Unkown
HY-115450 ONO-0300302 Antagonist 99.43% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LPAR1 VGNC VGNC:63261
Bos taurus LPAR1 VGNC VGNC:30955
Mus musculus LPAR1 MGD MGI:108429
Canis familiaris LPAR1 VGNC VGNC:42742
Rattus norvegicus LPAR1 RGD RGD:620563