EDNRB - endothelin receptor type B Gene

Homo sapiens

Also known as ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2

Gene ID: 1910 | Gene type: protein coding

About EDNRB

Cytogenetic location: 13q22.3 Genomic coordinates (GRCh38): 13:77,895,481-77,975,527 (from NCBI)

This gene has 8 transcripts (splice variants), 263 orthologues, 15 paralogues and is associated with 9 phenotypes. Broad expression in placenta (RPKM 49.8), lung (RPKM 38.6) and 21 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the Endothelin Receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

EDNRB Products(5)

mRNA	Protein	Name
NM_001201397.1	NP_001188326.1	endothelin receptor type B isoform 3
NM_000115.5	NP_000106.1	endothelin receptor type B isoform 1 precursor
NM_001122659.3	NP_001116131.1	endothelin receptor type B isoform 1 precursor
NR_047024.1
NM_003991.4	NP_003982.1	endothelin receptor type B isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endothelin receptor activity	IDA IDA: Inferred from direct assay	1713452	GOA
enables endothelin receptor activity	IMP IMP: Inferred from mutant phenotype	19767294	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	1713452	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	28236341	GOA
involved in endothelin receptor signaling pathway	IDA IDA: Inferred from direct assay	1713452	GOA
involved in endothelin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19767294	GOA
involved in macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	12207323	GOA
involved in negative regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	19767294	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19767294	GOA
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	8982507	GOA
involved in vein smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	8982507	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28236341	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDNRB Protein Structure

7tm_1

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

endothelin receptor type B

Hirschsprung disease 2	endothelin receptor non-selective type
endothelin receptor subtype B1

Recombinant EDNRB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74180	EDNRB/Endothelin R Type B Protein, Human (HEK293, His)	P24530/NP_000106.1 (E27-K101)	≥95%
HY-P74181	EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc)	P24530 (E27-K101)	≥95%
HY-P700379	EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His)	P24530 (E27-S442)	≥95%

Related Diseases

Diseases

Alias

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Impetigo

Palmoplantar Keratoderma, Punctate Type Iii

Acrokeratoelastoidosis Of Costa	Ake
Punctate Palmoplantar Keratoderma Type Iii	PPKP3
Keratoderma, Palmoplantar, Punctate Type 3	Punctate Palmoplantar Hyperkeratosis Type 3
Punctate Palmoplantar Keratoderma Type 3	Rare Form Of Hirschsprung'S Disease
Acrokeratoelastoidosis	Collagenous Plaques Of Hands And Feet
Aganglionosis, Total Intestinal	Collagenous Plaques Of Hand And Feet
Palmoplantar Keratoderma, Punctate Type 3	Aganglionosis, Total Colonic
Ntia	Near-Total Intestinal Aganglionosis
Tia

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Hernia, Congenital Diaphragmatic 1	Cdh
Congenital Diaphragmatic Defect	Hernia, Diaphragmatic
Dih	Hernia, Congenital Diaphragmatic
Hcd	Diaphragmatic Defect, Congenital
Diaphragm, Unilateral Agenesis Of	Hemidiaphragm, Agenesis Of
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hiatus Hernia	Oesophageal Hiatus Hernia
Paraoesophageal Hernia	Sliding Hiatus Hernia
Congenital Diaphragm Hernia	Congenital Diaphragm Defect With Hernia
Gross Congenital Diaphragm Defect

Lentigines

Lentigo

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease	Obstructive Disease Of The Pulmonary Veins
Pvod	Isolated Pulmonary Venous Sclerosis
Venous Form Of Primary Pulmonary Hypertension	Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Chronic Pulmonary Heart Disease

Piebald Trait

Piebaldism	PBT
Partial Albinism	Albinoidism, Oculocutaneous, Autosomal Dominant

Mowat-Wilson Syndrome

MOWS	Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease
Hirschsprung Disease-Mental Retardation Syndrome	Mowat-Wilson Syndrome Due To Monosomy 2q22
Hirschsprung Disease Mental Retardation Syndrome	Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease
Hirschsprung Disease - Intellectual Disability Syndrome	Hirschsprung Disease Intellectual Disability Syndrome
Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease	Mws
Hirschsprung Disease-Intellectual Disability Syndrome	Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion
Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)	Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22
Mowat-Wilson Syndrome Due To 2q22 Microdeletion	Mowat-Wilson Syndrome Due To Del(2)Q(22)
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Waardenburg'S Syndrome

Waardenburg Syndrome	Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome
Van Der Hoeve Halbertsona Waardenburg Syndrome	Waardenburg Shah Syndrome
Waardenburg, Types I And/Or Ii	Mende Syndrome
Waardenburgs Syndrome	Waardenburg Syndrome, Type 4a

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Central Hypoventilation Syndrome, Congenital, 1

Cchs	CCHS1
Central Hypoventilation Syndrome, Congenital	Congenital Failure Of Autonomic Control
Autonomic Control, Congenital Failure Of	Ondine Curse, Congenital
Central Hypoventilation Syndrome, Congenital, 1, With Or Without Hirschsprung Disease	Ondine Curse
Central Hypoventilation Syndrome, Congenital, 1, With Or Without Hirschsprung	Hypoventilation, Central, Syndrome, Congenital, Type 1
Congenital Central Hypoventilation	Sleep Apnea, Central
Central Alveolar Hypoventilation Syndrome	Cchs With Hirschsprung Disease
Congenital Central Alveolar Hypoventilation Syndrome	Sleep-Related Respiratory Failure
Hypoventilation

Double Pterygium

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome	GOSHS
Megacolon-Microcephaly Syndrome

Tietz Albinism-Deafness Syndrome

Tietz Syndrome	Albinism-Deafness Of Tietz
Hypopigmentation/Deafness Of Tietz	Tietze'S Syndrome
TADS	Costochondral Junction Syndrome
Costochondritis	Tietze Syndrome
Hypopigmentation-Deafness Syndrome	Costalchondritis
Slipping Rib Syndrome	Tietze'S Disease
Chondropathia Tuberosa	Albinism And Complete Nerve Deafness
Tietz'S Syndrome	Hypopigmentation-Hearing Loss Syndrome
Costal Chondritis	Abnormality Of The Costochondral Junction

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Congenital Megacolon
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	Hirschsprung'S Disease
Congenital Intestinal Aganglionosis	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Aganglionosis, Total Intestinal

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Hearing Loss Disorder
Hearing Loss, Sensorineural	Central Hearing Loss
High Frequency Deafness	High Frequency Hearing Loss
High-Frequency Hearing Loss	Perceptive Deafness
Perceptive Hearing Loss	Perceptive Hearing Loss Or Deafness
Sensorineural Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Olmsted Syndrome, X-Linked

OLMSX	Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked
Ppkmx	X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
X-Linked Olmsted Syndrome	Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Waardenburg Syndrome, Type 3

Waardenburg Syndrome Type 3	Klein-Waardenburg Syndrome
WS3	Waardenburg Syndrome With Upper Limb Anomalies
Waardenburg Syndrome Type Iii	Waardenburg Syndrome, Type Iii
White Forelock Syndrome With Multiple Congenital Malformations	Waardenburg Syndrome With Limb Anomalies
Waardenburg Syndrome 3	White Forelock With Malformations
Klein'S Syndrome

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Waardenburg Syndrome, Type 2e

Waardenburg Syndrome Type 2	Waardenburg Syndrome Type 2e
WS2E	Waardenburg Syndrome, Type 2e, With Or Without Neurologic Involvement
Waardenburg Syndrome, Type Iie	Hypogonadotropic Hypogonadism With Anosmia And Deafness With Or Without Hypopigmentation
Waardenburg Syndrome Type 2e With Or Without Neurologic Involvement	Waardenburg Syndrome Type Iie
Hypogonadotropic Hypogonadism With Anosmia And Deafness, With Or Without Hypopigmentation	Ws2e, With Or Without Neurologic Involvement
Ws2e With Or Without Neurological Involvement	Ws 2
Ws Type 2	Ws2
Waardenburg Syndrome Type Ii	Waardenburg Syndrome 2e
Kallmann Syndrome And Deafness With Or Without Hypopigmentation	Ws2e With Or Without Neurologic Involvement
Waardenburg Syndrome Type 2e, Without Neurologic Involvement	Ws-2

Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction	Chronic Intestinal Pseudo-Obstruction
Cipo	Neuronal Intestinal Dysplasia
Hollow Visceral Myopathy	Familial Visceral Neuropathy
Paralytic Ileus	Intestinal Pseudoobstruction
Chronic Idiopathic Intestinal Pseudo-Obstruction	Ciip
Congenital Short Bowel Syndrome	Enteric Neuropathy
Familial Visceral Myopathy	Ipo
Pseudo-Obstruction Of Intestine	Pseudointestinal Obstruction Syndrome
Pseudoobstructive Syndrome	Congenital Idiopathic Intestinal Pseudoobstruction
Visceral Myopathy, Familial

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Disease, Susceptibility To
Coronary Artery Anomaly	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Waardenburg Syndrome, Type 4c

Waardenburg Syndrome Type 4c	WS4C
Waardenburg Syndrome Type Ivc	Waardenburg Syndrome With Hirschsprung Disease Type 4c
Waardenburg Syndrome With Hirschsprung Disease, Type 4c	Waardenburg Syndrome, Type Ivc
Waardenburg Syndrome 4c	Hirschsprung Disease With Pigmentary Anomaly
Shah-Waardenburg Syndrome	Waardenburg-Shah Syndrome
Waardenburg Syndrome, Type 4a

Coffin-Lowry Syndrome

CLS	Mental Retardation With Osteocartilaginous Abnormalities
Coffin Syndrome 1	Coffin Syndrome
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Coffin Lowry Syndrome

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Constipation

Scarlet Fever

Scarlatina

Scarlatina Nos

Waardenburg Syndrome, Type 2a

Waardenburg Syndrome Type 2a	WS2A
Waardenburg Syndrome, Type Iia	Waardenburg Syndrome Without Dystopia Canthorum
Ws2	Waardenburg Syndrome Type Iia
Waardenburg Syndrome 2a

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Megacolon

Dilatation Of Colon

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Epilepsy, Familial Temporal Lobe, 6

ETL6	Familial Temporal Lobe Epilepsy 6

Hirschsprung Disease 2

Hirschsprung Disease, Susceptibility To, 2	HSCR2
Hirschsprung Disease Type 2	Aganglionic Megacolon
Mgc	Hirschsprung Disease, Susceptibility To, Type 2
Hirschsprung Disease

Podoconiosis

PDCOS	Podoconiosis, Susceptibility To
Nonfilarial Elephantiasis Of Lower Legs	Nonfilarial Elephantiasis Of Lower Legs, Susceptibility To
Endemic Nonfilarial Elephantiasis	Endemic Nonfilarial Elephantiasis, Susceptibility To
Lymphostatic Verrucosis	Lymphostatic Verrucosis, Susceptibility To
Elephantiasis	Endemic Non-Filarial Elephantiasis

Acquired Color Blindness

Acquired Color Vision Deficiencies	Acquired Color Vision Deficiency
Acquired Colour Blindness	Acquired Colour Vision Deficiencies
Acquired Colour Vision Deficiency

Bullous Impetigo

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Sigmoid Disease

Sigmoid Diseases

Pyoderma

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Gingival Overgrowth

Gingival Enlargement	Gingival Hyperplasia
Gingival Bulge	Gingival Enlargement Nos
Gingival Hypertrophy	Gum Hypertrophy
Hyperplasia Gum	Gingival Thickening
Hyperplasia Of Gingiva	Hypertrophy Of Gingiva
Hypertrophy Of Mucous Membrane Of Gums

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Cochlear Disease

Cochlear Diseases

Hepatopulmonary Syndrome

Rare Genetic Deafness

Rare Genetic Hearing Loss

Proctitis

Ulcerative Proctitis	Chronic Ulcerative Proctitis
Idiopathic Proctitis	Nonspecific Ulcerative Proctitis
Ulcerative Colitis Confined To Rectum	Ip - [Idiopathic Proctitis]
Chronic Ulcerative Proctitis Nos

Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease

Pcwh Syndrome	PCWH
Neurologic Waardenburg-Shah Syndrome	Waardenburg-Shah Syndrome, Neurologic Variant
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Hirschsprung Disease-Waardenburg Syndrome	Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Ws4 Plus	Peripheral Demyelinating Neuropathy, Central Dysmyelinating Leukodystrophy, Waardenburg Syndrome And Hirschsprung Disease
Waardenburg-Shah Syndrome Neurologic Variant

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Commensal Bacterial Infectious Disease

Transient Refractive Change

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Idiopathic Pulmonary Hypertension
Idiopathic Pulmonary Arterial Hypertension	Pulmonary Htn - [Hypertension]

Chromosome 17q12 Duplication Syndrome

17q12 Microduplication Syndrome	Trisomy 17q12
17q12 Duplication	17q12 Microduplication
Dup(17)(Q12)	Recurrent Duplication Of 17q12
17q12 Duplication Syndrome	17q12 Recurrent Duplication

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Waardenburg Syndrome, Type 2d

Waardenburg Syndrome Type 2d	WS2D
Waardenburg Syndrome, Type Iid	Waardenburg Syndrome Type Iid
Waardenburg Syndrome 2d

Pyomyositis

Tropical Pyomyositis	Myositis Purulenta Tropica
Myositis Tropicans	Pm
Suppurative Myositis	Purulent Myositis

Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1	WS1
Waardenburg Syndrome Type I	Waardenburg Syndrome With Dystopia Canthorum
Waardenburg'S Syndrome Type 1	Waardenburg Syndrome 1
Waardenburg Syndrome, Type I	Waardenburg Syndrome

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04169	EDNRB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04170	Ednrb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04171	Ednrb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EDNRB	MGD	MGI:102720
Macaca mulatta	EDNRB	VGNC	VGNC:72160
Bos taurus	EDNRB	VGNC	VGNC:28330
Canis familiaris	EDNRB	VGNC	VGNC:40203
Rattus norvegicus	EDNRB	RGD	RGD:2536
Felis catus	EDNRB	VGNC	VGNC:61728
Others	EDNRB	NCBI