Prx - periaxin Gene

Mus musculus

Also known as L-Periaxin

Gene ID: 19153 | Gene type: protein coding

About Prx

Summary

Involved in several processes, including myelination in peripheral nervous system; regulation of RNA splicing; and transmission of nerve impulse. Located in cytosol; nuclear speck; and plasma membrane. Is expressed in sciatic nerve. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Apr 2022]

Prx Products(2)

mRNA	Protein	Name
NM_019412.2	NP_062285.1	periaxin isoform S
NM_198048.2	NP_932165.2	periaxin isoform L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11430802	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in peripheral nervous system myelin formation	IMP IMP: Inferred from mutant phenotype	10839370	MGI
involved in peripheral nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	10839370	MGI
involved in regulation of RNA splicing	IDA IDA: Inferred from direct assay	21940993	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	10839370	MGI
involved in transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	10839370	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15282162	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9488714	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	21940993	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15282162	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9488714	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

periaxin

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99554	Topsalysin		/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14848	Naluzotan		98.05%	Phase 3
HY-15472	PRX-08066	Antagonist	97.46%	Phase 2
HY-19846	VRX-03011	Agonist	/	Phase 2
HY-14559	PRX-07034 hydrochloride	Antagonist	98.97%	Phase 1
HY-100171A	PRX933	Agonist	/	Phase 1

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99405	Prasinezumab	Inhibitor	99.90%	Phase 2
HY-P990708	Bizaxofusp		/	Phase 2
HY-P99543	Tulinercept	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14848A	Naluzotan hydrochloride		99.63%	Unkown
HY-100171	PRX933 hydrochloride	Agonist	/	Unkown
HY-15472A	PRX-08066 maleate	Antagonist	/	Unkown
HY-158198	PRXS571	Modulator	/	Unkown
HY-RS11265	PRX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prx	NCBI	NCBI:57716

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