Topsalysin (Synonyms: PRX-302)

Cat. No.: HY-P99554: FAQs
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Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle.

For research use only. We do not sell to patients.

CAS No. : 917121-25-6

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Description

Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle^[1].

Species

Aeromonas hydrophila

In Vitro

Topsalysin (19 pM-10 nM; 48 h) shows prostate-specific antigen (PSA)-dependent toxicity against LNCaP, PC3, DU145, and TSU cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Topsalysin (intratumor injection; 1-10 μg/mouse; single dose) inhibits tumor growth in mice bearing^[1].
Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL; i.p.; single dose) could kill up to 50% of cells in the injected site of cynomolgus monkey prostate glands^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice (6-week-old) subcutaneously bearing tumors^[1]
Dosage:	0, 1, 5, and 10 μg
Administration:	Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
Result:	Showed prostate-specific antigen (PSA)-dependent toxicity in mice.

Clinical Trial

CAS No.

917121-25-6

SMILES

[Topsalysin]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

proaerolysin (engineered with a PSA cutting site)-hexahistidine

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Williams SA, et al. A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease. J Natl Cancer Inst. 2007 Mar 7;99(5):376-85. [Content Brief]

Topsalysin Related Classifications

Inhibitory Antibodies

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topsalysin917121-25-6PRX-302PRX302PRX 302OthersInhibitorinhibitorinhibit

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