2. Gene
  3. Psap - prosaposin Gene

Psap - prosaposin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SGP-1

Gene ID: 19156 | Gene type: protein coding

About Psap

Summary

This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes proteolytic processing to generate four different polypeptides known as saposin A, B, C or D, that are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. Alternately, the encoded protein is secreted into body fluids where it exhibits neurotrophic and myelinotrophic activities. A complete lack of the encoded protein is fatal to mice either at the neonatal stage or within the first month due to severe leukodystrophy and sphingolipid accumulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature saposins. [provided by RefSeq, Sep 2015]

Psap Products(6)

mRNA Protein Name
NM_001146120.1 NP_001139592.1 prosaposin isoform A precursor
NM_001146121.1 NP_001139593.1 prosaposin isoform C precursor
NM_001146122.1 NP_001139594.1 prosaposin isoform D precursor
NM_001146123.1 NP_001139595.1 prosaposin isoform E precursor
NM_001146124.1 NP_001139596.1 prosaposin isoform F
NM_011179.3 NP_035309.3 prosaposin isoform B precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
23690594 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12867159 MGI
enables lipid antigen binding IDA
IDA: Inferred from direct assay
14684827 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14684827 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
14684827 MGI
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
23690594 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
14684827 MGI
involved in cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
23690594 MGI
acts upstream of or within ceramide metabolic process IMP
IMP: Inferred from mutant phenotype
15345707 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
15345707 MGI
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
17167097 MGI
acts upstream of or within corneocyte development IMP
IMP: Inferred from mutant phenotype
24872419 MGI
acts upstream of or within cornified envelope assembly IMP
IMP: Inferred from mutant phenotype
24872419 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
11105903 MGI
acts upstream of or within epithelial cell differentiation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
11105903 MGI
acts upstream of or within galactosylceramide catabolic process IMP
IMP: Inferred from mutant phenotype
11371512 MGI
acts upstream of or within negative effect gene expression IDA
IDA: Inferred from direct assay
27356620 MGI
acts upstream of or within negative effect gene expression IMP
IMP: Inferred from mutant phenotype
27356620 MGI
acts upstream of or within glucosylceramide metabolic process IMP
IMP: Inferred from mutant phenotype
17353235 MGI
acts upstream of or within glycolipid metabolic process IMP
IMP: Inferred from mutant phenotype
12810822 MGI
acts upstream of or within inclusion body assembly IMP
IMP: Inferred from mutant phenotype
9678511 MGI
acts upstream of or within intracellular protein transport IMP
IMP: Inferred from mutant phenotype
17353235 MGI
acts upstream of or within lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
12813057 MGI
acts upstream of or within membrane lipid metabolic process IDA
IDA: Inferred from direct assay
14684827 MGI
acts upstream of or within micturition IMP
IMP: Inferred from mutant phenotype
11371512 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
11371512 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
9678511 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
22326583 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
23690594 MGI
acts upstream of or within positive regulation of hydrolase activity IMP
IMP: Inferred from mutant phenotype
11371512 MGI
acts upstream of or within prostate gland growth IMP
IMP: Inferred from mutant phenotype
11105903 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
17353235 MGI
acts upstream of or within regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
11105903 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
18480170 MGI
acts upstream of or within renal system development IMP
IMP: Inferred from mutant phenotype
15345707 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
17167097 MGI
acts upstream of or within sphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
11371512 MGI
acts upstream of or within walking behavior IMP
IMP: Inferred from mutant phenotype
22326583 MGI
Cellular Component GO Annotation Evidence Reference Source
located in aggresome IDA
IDA: Inferred from direct assay
20498017 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19732768 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
19732768 MGI
located in lysosome IDA
IDA: Inferred from direct assay
12867159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prosaposin

snoRNA MBII-198

sulfated glycoprotein 1

Recombinant Psap Proteins

Cat. No. Product Name Accession Purity
HY-P77159 PSAP/Prosaposin Protein, Mouse (HEK293, His) Q61207/NP_035309.3 (S17-N557) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-157926 Nitroso-PSAP / Unkown
HY-RS11269 PSAP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psap NCBI NCBI:5660
Rattus norvegicus Psap NCBI NCBI:25524