Ptafr - platelet-activating factor receptor Gene

Mus musculus

Also known as PAFR

Gene ID: 19204 | Gene type: protein coding

About Ptafr

Chromosome 4: 132,291,378-132,309,994 forward strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 223 orthologues, 6 paralogues and is associated with 8 phenotypes. Broad expression in mammary gland adult (RPKM 12.2), subcutaneous fat pad adult (RPKM 7.6) and 16 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to Bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]

Ptafr Products(1)

mRNA	Protein	Name
NM_001081211.2	NP_001074680.1	platelet-activating factor receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipopolysaccharide binding	IMP IMP: Inferred from mutant phenotype	9013981	MGI
enables lipopolysaccharide immune receptor activity	IMP IMP: Inferred from mutant phenotype	9013981	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	14742561	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	14742561	MGI
acts upstream of or within inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	9013981	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	9013981	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptafr Protein Structure

7tmA_PAFR

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

platelet-activating factor receptor

PAF receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11347	PTAFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11348	Ptafr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11349	Ptafr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptafr	NCBI	NCBI:5724

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