Ptgdr - prostaglandin D receptor Gene

Mus musculus

Also known as DP; PGD

Gene ID: 19214 | Gene type: protein coding

About Ptgdr

Chromosome 14: 45,088,692-45,096,832 reverse strand.GRCm39:CM001007.3

This gene has 1 transcript (splice variant), 117 orthologues, 7 paralogues and is associated with 18 phenotypes. Biased expression in testis adult (RPKM 1.2), CNS E18 (RPKM .5) and 14 other tissues.

Summary

Enables prostaglandin D receptor activity and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenosine metabolic process; cellular response to prostaglandin D stimulus; and male sex determination. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptgdr Products(1)

mRNA	Protein	Name
NM_008962.4	NP_032988.3	prostaglandin D2 receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables prostaglandin D receptor activity	IDA IDA: Inferred from direct assay	12878180	MGI
enables prostaglandin J receptor activity	IDA IDA: Inferred from direct assay	12878180	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenosine metabolic process	IMP IMP: Inferred from mutant phenotype	11562489	MGI
acts upstream of or within cellular response to prostaglandin D stimulus	IMP IMP: Inferred from mutant phenotype	11562489	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15834430	MGI
acts upstream of or within male sex determination	IMP IMP: Inferred from mutant phenotype	16185683	MGI
acts upstream of or within sleep	IMP IMP: Inferred from mutant phenotype	11562489	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11562489	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptgdr Protein Structure

7tm_GPCRs

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

prostaglandin D2 receptor

PGD receptor	PGD2 receptor
prostanoid DP receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11368	PTGDR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11369	Ptgdr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11370	PTGDR Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11371	PTGDR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11372	Ptgdr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11373	Ptgdr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptgdr	NCBI	NCBI:5729

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