2. Gene
  3. Nectin2 - nectin cell adhesion molecule 2 Gene

Nectin2 - nectin cell adhesion molecule 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MPH; Pvr; Pvs; Cd112; Pvrl2; nectin-2

Gene ID: 19294 | Gene type: protein coding

About Nectin2

Summary

Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid development. Located in cell-cell contact zone; plasma membrane; and zonula adherens. Is expressed in brain; cochlea; enamel organ; male reproductive system; and primitive collecting duct. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]

Nectin2 Products(2)

mRNA Protein Name
NM_001159724.1 NP_001153196.1 nectin-2 isoform 2 precursor
NM_008990.3 NP_033016.3 nectin-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
10225955 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22902367 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12759359 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12826663 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within acrosome assembly IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within cellular anatomical entity morphogenesis IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within cilium organization IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within establishment of mitochondrion localization IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
10733589 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
acts upstream of or within sperm mitochondrion organization IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
10733589 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
10733589 MGI
acts upstream of or within spermatid nucleus differentiation IMP
IMP: Inferred from mutant phenotype
10733589 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical junction complex IDA
IDA: Inferred from direct assay
22512338 MGI
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
23533177 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
15660130 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12826663 MGI
located in zonula adherens IDA
IDA: Inferred from direct assay
10225955 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nectin-2

herpes virus entry mediator B

herpesvirus entry mediator B

hveB

mHveB

murine herpes virus entry protein B

murine herpesvirus entry protein B

poliovirus receptor homolog

poliovirus receptor-related 2

poliovirus receptor-related protein 2

polioviru

Recombinant Nectin2 Proteins

Cat. No. Product Name Accession Purity
HY-P7781 Nectin-2/CD112 Protein, Mouse (HEK293, His) P32507 (Q32-G351) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09175 NECTIN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nectin2 NCBI NCBI:5819
Macaca fascicularis Nectin2 NCBI NCBI:102137456