2. Gene
  3. NECTIN2 - nectin cell adhesion molecule 2 Gene

NECTIN2 - nectin cell adhesion molecule 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HVEB; PRR2; CD112; PVRL2; PVRR2

Gene ID: 5819 | Gene type: protein coding

About NECTIN2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,846,297-44,889,223 (from NCBI)

This gene has 6 transcripts (splice variants), 428 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 24.8), testis (RPKM 23.6) and 25 other tissues.

Summary

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NECTIN2 Products(2)

mRNA Protein Name
NM_001042724.2 NP_001036189.1 nectin-2 isoform delta precursor
NM_002856.3 NP_002847.1 nectin-2 isoform alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
9845526 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
9845526 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adhesion of symbiont to host IDA
IDA: Inferred from direct assay
12915581 GOA
involved in coreceptor-mediated virion attachment to host cell IDA
IDA: Inferred from direct assay
12915581 GOA
involved in fusion of virus membrane with host plasma membrane IDA
IDA: Inferred from direct assay
12915581 GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
9845526 GOA
involved in positive regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
26755705 GOA
involved in positive regulation of immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
16831868 GOA
involved in positive regulation of mast cell activation IMP
IMP: Inferred from mutant phenotype
16831868 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16304049 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
12913096 GOA
involved in regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
11602758 GOA
involved in susceptibility to T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15039383 GOA
involved in susceptibility to natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
12913096 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16831868 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
9845526 GOA
located in membrane IDA
IDA: Inferred from direct assay
12913096 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (38 - 152)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (167 - 248)

Ig_2

Ig_2: Immunoglobulin domain (277 - 336)

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  • 538 a.a.
Protein Preferred Names Protein Names

nectin-2

herpesvirus entry protein B

NECTIN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NECTIN2 Q92692 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
NECTIN2 Q92692 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
NECTIN2 Q92692 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
NECTIN2 Q92692 NECTIN3 Homo sapiens Q9NQS3
SPR
23758976
Intra
NECTIN2 Q92692 NECTIN3 Homo sapiens Q9NQS3
Protein Array
21982860
Intra
NECTIN2 Q92692 AFDN Homo sapiens P55196
Anti Bait CoIP
23750010
Intra
NECTIN2 Q92692 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
NECTIN2 Q92692 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
NECTIN2 Q92692 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
Solution Sedimentation
22902367
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
GMS
22927415
Intra
NECTIN2 Q92692 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
SPR
22902367
Intra
NECTIN2 Q92692 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
GMS
28515320
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
ELISA
23758976
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
Solution Sedimentation
22927415
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
Protein Array
21982860
Intra
NECTIN2 Q92692 NECTIN2 Homo sapiens Q92692
X-Ray Diffraction
22927415
Intra
NECTIN2 Q92692 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
NECTIN2 Q92692 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN2 Proteins

Cat. No. Product Name Accession Purity
HY-P7780 Nectin-2/CD112 Protein, Human (HEK293, His) Q92692-2 (Q32-L360) ≥95%
HY-P72400 Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) Q92692-2 (Q32-L360) ≥95%
HY-P73307 Nectin-2/CD112 Protein, Human (HEK293) Q92692-2/NP_002847.1 (Q32-L360) ≥95%
HY-P78372 Nectin-2/CD112 Protein, Human (HEK293, Fc) Q92692-2 /NP_002847.1(Q32-L360) ≥95%
HY-P78495 Nectin-2/CD112 Protein, Human (HEK293, His-Avi) Q92692-2 (Q32-L360) ≥95%

NECTIN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81451 Nectin 2 Antibody (YA1196) IHC-P Human

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Ovarian Cystic Teratoma
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09175 NECTIN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NECTIN2 RGD RGD:1309505
Bos taurus NECTIN2 VGNC VGNC:52209
Mus musculus NECTIN2 MGD MGI:97822
Macaca mulatta NECTIN2 VGNC VGNC:75396
Canis familiaris NECTIN2 VGNC VGNC:53741
Macaca fascicularis NECTIN2 NCBI NCBI:102137456
Others NECTIN2 NCBI