EGR3 - early growth response 3 Gene

Homo sapiens

Also known as EGR-3; PILOT

Gene ID: 1960 | Gene type: protein coding

About EGR3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,687,659-22,693,480 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 4 paralogues. Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues.

Summary

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

EGR3 Products(3)

mRNA	Protein	Name
NM_001199880.2	NP_001186809.1	early growth response protein 3 isoform 2
NM_001199881.2	NP_001186810.1	early growth response protein 3 isoform 3
NM_004430.3	NP_004421.2	early growth response protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	18059339	GOA
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18059339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EGR3 Protein Structure

DUF3446

zf-H2C2_2

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

early growth response protein 3

zinc finger protein pilot

Related Diseases

Diseases

Alias

Patella, Chondromalacia Of

Chondromalacia Patellae	Chondromalacia Of Patella
Softening Of Articular Cartilage Of Patella	Patellofemoral Pain Syndrome
Patellofemoral Chondromalacia

Schizophrenia 19

SCZD19	Schizophrenia 19 With Or Without An Affective Disorder
Schizophrenia 19, Susceptibility To	{Schizophrenia 19, Susceptibility To}

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04217	EGR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EGR3	VGNC	VGNC:28368
Felis catus	EGR3	VGNC	VGNC:61761
Canis familiaris	EGR3	VGNC	VGNC:40242
Macaca mulatta	EGR3	VGNC	VGNC:104449
Rattus norvegicus	EGR3	RGD	RGD:2545
Mus musculus	EGR3	MGD	MGI:1306780

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