Rela - v-rel reticuloendotheliosis viral oncogene homolog A (avian) Gene

Mus musculus

Also known as p65; p65 NFkB; p65 NF-kappa B

Gene ID: 19697 | Gene type: protein coding

About Rela

Chromosome 19: 5,687,511-5,698,158 forward strand.GRCm39:CM001012.3

This gene has 7 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 47 phenotypes. Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; postsynapse to nucleus signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to lipopolysaccharide; and positive regulation of interleukin-12 production. Located in several cellular components, including chromatin; cytosol; and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela Products(3)

mRNA	Protein	Name
NM_001402548.1	NP_001389477.1	transcription factor p65 isoform p65 iso 3
NM_009045.5	NP_033071.1	transcription factor p65 isoform 1
NM_001365067.1	NP_001351996.1	transcription factor p65 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10227969	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21329555	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14568984	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	29813070	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8289784	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25152367	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15944286	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables actinin binding	IPI IPI: Inferred from physical interaction	25411248	MGI
enables ankyrin repeat binding	IPI IPI: Inferred from physical interaction	21131967	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19619491	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	22244329	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19338389	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9556555	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21131967	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23184950	MGI
enables transcription regulator activity	IDA IDA: Inferred from direct assay	35087169	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29813070	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9120401	MGI
acts upstream of or within cellular response to biotic stimulus	IDA IDA: Inferred from direct assay	23262141	MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21072211	MGI
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20547752	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	29813070	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	9120401	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	16481354	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	7603567	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	22244329	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22244329	MGI
acts upstream of or within negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	15923614	MGI
involved in negative regulation of protein sumoylation	IDA IDA: Inferred from direct assay	25152367	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25152367	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14568984	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21131967	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18505784	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	22244329	MGI
acts upstream of positive regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	21329555	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	22244329	MGI
acts upstream of or within positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	14568984	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21329555	MGI
acts upstream of protein catabolic process	IMP IMP: Inferred from mutant phenotype	15923614	MGI
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	21131967	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24501220	MGI
acts upstream of or within response to bacterium	IDA IDA: Inferred from direct assay	15661922	MGI
acts upstream of or within response to muramyl dipeptide	IDA IDA: Inferred from direct assay	12527755	MGI
acts upstream of or within response to muscle stretch	IDA IDA: Inferred from direct assay	20442316	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NF-kappaB p50/p65 complex	IDA IDA: Inferred from direct assay	2001591	MGI
located in chromatin	IDA IDA: Inferred from direct assay	25152367	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11567019	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11931770	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10227969	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	2001591	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rela Protein Structure

RHD-n_RelA

IPT_NFkappaB

PHA03247

0
100
200
300
400
500
549 a.a.

Protein Preferred Names

Protein Names

transcription factor p65

avian reticuloendotheliosis viral (v-rel) oncogene homolog A	nuclear factor NF-kappa-B p65 subunit
nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases Unkown
HY-RS11826	RELA Human Pre-designed siRNA Set A	/	Unkown
HY-RS11827	Rela Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11828	Rela Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rela	NCBI	NCBI:5970
Canis familiaris	Rela	NCBI	NCBI:483729
Macaca fascicularis	Rela	NCBI	NCBI:101867324
Canis lupus familiaris	Rela	NCBI
Rattus norvegicus	Rela	NCBI	NCBI:309165
Macaca mulatta	Rela	NCBI	NCBI:715919

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