LDHD - lactate dehydrogenase D Gene

Homo sapiens

Also known as DLD; DLACD

Gene ID: 197257 | Gene type: protein coding

About LDHD

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,111,864-75,116,780 (from NCBI)

This gene has 4 transcripts (splice variants), 188 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 28.2), liver (RPKM 23.6) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

LDHD Products(2)

mRNA	Protein	Name
NM_153486.4	NP_705690.2	probable D-lactate dehydrogenase, mitochondrial isoform 1 precursor
NM_194436.3	NP_919417.1	probable D-lactate dehydrogenase, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12127981	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lactate catabolic process	IMP IMP: Inferred from mutant phenotype	30931947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHD Protein Structure

FAD_binding_4

FAD-oxidase_C

0
100
200
300
400
507 a.a.

Protein Preferred Names

Protein Names

probable D-lactate dehydrogenase, mitochondrial

D-lactate dehydrogenase

Related Diseases

Diseases

Alias

D-Lactic Aciduria With Gout

DLACD	Uric Acid Concentration, Serum, Quantitative Trait Locus 7
Uaqtl7	Gout 5
Gout, Susceptibility To, 5	Gout5
D-Lactic Aciduria With Susceptibility To Gout

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Cataract 6, Multiple Types

Ctpp1	Cataract 6 Multiple Types
CTRCT6	Cataract, Posterior Polar, 1
Arcc2	Cataract, Age-Related Cortical, 2
Ctpa	Ctpp
Age Related Cortical Cataract 2	Posterior Polar Cataract 1
Posterior Polar Cataract, 1	Age-Related Cortical Cataract 2
Cataract Posterior Polar 1

Hyperphenylalaninemia, Bh4-Deficient, A

6-Pyruvoyl-Tetrahydropterin Synthase Deficiency	Pts Deficiency
HPABH4A	Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency
Ptsd	Bh4-Deficient Hyperphenylalaninemia A
Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency	Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency
Hyperphenylalanemia, Bh4-Deficient, A	Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
6-Pyruvoyltetrahydropterin Synthase Deficiency	Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency
Ptpsd	Hyperphenylalaninemia, Bh4-Deficient, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07574	LDHD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LDHD	MGD	MGI:106428
Bos taurus	LDHD	VGNC	VGNC:30825
Rattus norvegicus	LDHD	RGD	RGD:1308107
Felis catus	LDHD	VGNC	VGNC:63209
Macaca mulatta	LDHD	VGNC	VGNC:74084
Canis familiaris	LDHD	VGNC	VGNC:42621

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