FCSK - fucose kinase Gene

Homo sapiens

Also known as FUK; CDGF2; 1110046B12Rik

Gene ID: 197258 | Gene type: protein coding

About FCSK

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,454,595-70,480,274 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and is associated with 2 phenotypes. Ubiquitous expression in duodenum (RPKM 3.1), kidney (RPKM 2.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This Enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

FCSK Products(1)

mRNA	Protein	Name
NM_145059.3	NP_659496.2	L-fucose kinase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fucokinase activity	IMP IMP: Inferred from mutant phenotype	30503518	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GDP-L-fucose salvage	IMP IMP: Inferred from mutant phenotype	30503518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCSK Protein Structure

Fucokinase

GHMP_kinases_N

GHMP_kinases_C

0
200
400
600
800
1000
1084 a.a.

Protein Preferred Names

Protein Names

L-fucose kinase

fucokinase

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation With Defective Fucosylation 2

CDGF2

Periventricular Leukomalacia

Leukomalacia, Periventricular	Pvl
Leukomalacia Periventricular

Pentosuria

Xylitol Dehydrogenase Deficiency	L-Xylulosuria
L-Xylulose Reductase Deficiency	Essential Pentosuria
PNTSU	Essential Benign Pentosuria

Schizophrenia 18

SCZD18	Schizophrenia 18 With Or Without An Affective Disorder
Schizophrenia Susceptibility 18	Chromosome 7q36.3 Duplication Syndrome, 362-Kb
Schizophrenia, Type 18

Schizophrenia 15

SCZD15	Schizophrenia 15 With Or Without An Affective Disorder
Schizophrenia Susceptibility Locus, Chromosome 22q13-Related	Schizophrenia Susceptibility Locus Chromosome 22q13-Related
Schizophrenia, Type 15

Oculogyric Crisis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04850	FCSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FCSK	MGD	MGI:1916071
Macaca mulatta	FCSK	VGNC	VGNC:72600
Felis catus	FCSK	VGNC	VGNC:62219
Bos taurus	FCSK	VGNC	VGNC:29142
Canis familiaris	FCSK	VGNC	VGNC:41006
Rattus norvegicus	FCSK	RGD	RGD:1307000

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