Rora - RAR-related orphan receptor alpha Gene

Mus musculus

Also known as sg; ROR1; ROR2; ROR3; Nr1f1; nmf267; tmgc26; staggerer; 9530021D13Rik

Gene ID: 19883 | Gene type: protein coding

About Rora

Chromosome 9: 68,561,068-69,295,528 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 104 phenotypes. Broad expression in cerebellum adult (RPKM 8.5), cortex adult (RPKM 3.) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rora Products(3)

mRNA	Protein	Name
NM_001289917.1	NP_001276846.1	nuclear receptor ROR-alpha isoform 3
NM_013646.2	NP_038674.1	nuclear receptor ROR-alpha isoform 1
NM_001289916.1	NP_001276845.1	nuclear receptor ROR-alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7838158	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7838156	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18164222	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15199055	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	14687547	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17110330	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18055760	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17476214	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	18164222	MGI
acts upstream of or within cGMP metabolic process	IMP IMP: Inferred from mutant phenotype	7518067	MGI
acts upstream of or within cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19955433	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	19955433	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	8996814	MGI
involved in cerebellar granule cell precursor proliferation	IMP IMP: Inferred from mutant phenotype	14687547	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	18055760	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	22753030	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	19324970	MGI
acts upstream of or within nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	7518067	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21628546	MGI
involved in positive regulation of circadian rhythm	IDA IDA: Inferred from direct assay	22753030	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15199055	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15199055	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7838156	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18055760	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23172836	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	19965867	MGI
acts upstream of or within regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	1565842	MGI
involved in regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	14687547	MGI
involved in regulation of steroid metabolic process	IMP IMP: Inferred from mutant phenotype	17666523	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18164222	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19324970	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	11053433	MGI
involved in xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	17666523	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18055760	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rora Protein Structure

NR_DBD_ROR

NR_LBD_ROR_like

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

nuclear receptor ROR-alpha

RAR-related orphan receptor A	nuclear receptor RZR-alpha
nuclear receptor subfamily 1 group F member 1	retinoid-related orphan receptor-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12126	RORA Human Pre-designed siRNA Set A		/	Unkown
HY-RS12127	Rora Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12128	RORA Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rora	NCBI	NCBI:6095

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