RDM1 - RAD52 motif containing 1 Gene

Homo sapiens

Also known as RAD52B

Gene ID: 201299 | Gene type: protein coding

About RDM1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,918,080-35,930,773 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 193 orthologues. Biased expression in testis (RPKM 2.2), lymph node (RPKM 0.3) and 5 other tissues.

Summary

This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]

RDM1 Products(9)

mRNA	Protein	Name
NM_001034836.2	NP_001030008.1	RAD52 motif-containing protein 1 isoform 2
NM_001163120.2	NP_001156592.1	RAD52 motif-containing protein 1 isoform 3
NM_001163121.2	NP_001156593.1	RAD52 motif-containing protein 1 isoform 4
NM_001163122.1	NP_001156594.1	RAD52 motif-containing protein 1 isoform 5
NM_001163124.1	NP_001156596.1	RAD52 motif-containing protein 1 isoform 6
NM_001163125.1	NP_001156597.1	RAD52 motif-containing protein 1 isoform 7
NM_001163130.1	NP_001156602.1	RAD52 motif-containing protein 1 isoform 8
NM_001330194.2	NP_001317123.1	RAD52 motif-containing protein 1 isoform 9
NM_145654.4	NP_663629.1	RAD52 motif-containing protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RDM1 Protein Structure

RRM_1

Rad52_Rad22

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

RAD52 motif-containing protein 1

RAD52 homolog B

RDM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RDM1	Q8NG50	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	RDM1	Q8NG50	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956
Intra	RDM1	Q8NG50	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plummer'S Disease

Toxic Nodular Goiter	Plummer Disease
Goiter Toxic Nodular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11805	RDM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RDM1	RGD	RGD:1310432
Macaca mulatta	RDM1	VGNC	VGNC:76778
Bos taurus	RDM1	VGNC	VGNC:33844
Mus musculus	RDM1	MGD	MGI:1913849
Others	RDM1	NCBI

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