Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Mus musculus

Also known as Fxr; HRR1; RIP14; Rxrip14

Gene ID: 20186 | Gene type: protein coding

About Nr1h4

Chromosome 10: 89,290,096-89,369,447 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 65 phenotypes. Biased expression in large intestine adult (RPKM 22.6), liver adult (RPKM 18.8) and 1 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid binding activity; and retinoid X receptor binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including Notch signaling pathway; bile acid metabolic process; and negative regulation of very-low-density lipoprotein particle remodeling. Predicted to be located in euchromatin and nucleus. Predicted to be part of receptor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; liver; sensory organ; and urinary system. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products(4)

mRNA	Protein	Name
NM_001385711.1	NP_001372640.1	bile acid receptor isoform 4
NM_001163700.1	NP_001157172.1	bile acid receptor isoform 1
NM_001163504.1	NP_001156976.1	bile acid receptor isoform 2
NM_009108.2	NP_033134.2	bile acid receptor isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27471003	MGI
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	7760852	MGI
enables bile acid binding	IMP IMP: Inferred from mutant phenotype	21757002	MGI
enables bile acid nuclear receptor activity	IMP IMP: Inferred from mutant phenotype	21757002	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	27471003	MGI
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	7760852	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14729567	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	12917447	MGI
involved in cell-cell junction assembly	IMP IMP: Inferred from mutant phenotype	16473946	MGI
involved in cellular response to bile acid	IMP IMP: Inferred from mutant phenotype	21757002	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	12421815	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	16473946	MGI
involved in fatty acid homeostasis	IMP IMP: Inferred from mutant phenotype	16557297	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	14729567	MGI
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	16446356	MGI
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of interleukin-1 production	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	21242261	MGI
involved in negative regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757002	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18972444	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18972444	MGI
acts upstream of or within negative regulation of very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	27471003	MGI
involved in nuclear receptor-mediated bile acid signaling pathway	IMP IMP: Inferred from mutant phenotype	21757002	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27471003	MGI
involved in positive regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	16446356	MGI
involved in positive regulation of ammonia assimilation cycle	IMP IMP: Inferred from mutant phenotype	21757002	MGI
involved in positive regulation of glutamate metabolic process	IMP IMP: Inferred from mutant phenotype	21757002	MGI
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	16446356	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	20447400	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24211198	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757002	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7760852	MGI
involved in regulation of urea metabolic process	IMP IMP: Inferred from mutant phenotype	21757002	MGI
involved in toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	23372731	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24211198	MGI
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	12891557	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr1h4 Protein Structure

NR_DBD_FXR

NR_LBD_Fxr

0
100
200
300
400
484 a.a.

Protein Preferred Names

Protein Names

bile acid receptor

RXR-interacting protein 14	farnesoid X activated receptor
farnesol receptor HRR-1	retinoid X receptor-interacting protein 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125996	NR1H4 activator 1	Agonist	/	Unkown
HY-RS09531	NR1H4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09532	Nr1h4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09533	Nr1h4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1h4	NCBI	NCBI:9971

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