2. Gene
  3. Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fxr; HRR1; RIP14; Rxrip14

Gene ID: 20186 | Gene type: protein coding

About Nr1h4

Chromosome 10: 89,290,096-89,369,447 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 65 phenotypes. Biased expression in large intestine adult (RPKM 22.6), liver adult (RPKM 18.8) and 1 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid binding activity; and retinoid X receptor binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including Notch signaling pathway; bile acid metabolic process; and negative regulation of very-low-density lipoprotein particle remodeling. Predicted to be located in euchromatin and nucleus. Predicted to be part of receptor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; liver; sensory organ; and urinary system. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products(4)

mRNA Protein Name
NM_001385711.1 NP_001372640.1 bile acid receptor isoform 4
NM_001163700.1 NP_001157172.1 bile acid receptor isoform 1
NM_001163504.1 NP_001156976.1 bile acid receptor isoform 2
NM_009108.2 NP_033134.2 bile acid receptor isoform 3

Nr1h4 Protein Structure

NR_DBD_FXR

NR_DBD_FXR: cd06962 (134 - 217)

NR_LBD_Fxr

NR_LBD_Fxr: cd06936 (259 - 478)

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  • 484 a.a.
Protein Preferred Names Protein Names

bile acid receptor

RXR-interacting protein 14

farnesoid X activated receptor

farnesol receptor HRR-1

retinoid X receptor-interacting protein 14

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125996 NR1H4 activator 1 Agonist / Unkown
HY-RS09531 NR1H4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09532 Nr1h4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09533 Nr1h4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h4 NCBI NCBI:9971