EN2 - engrailed homeobox 2 Gene

Homo sapiens

Gene ID: 2020 | Gene type: protein coding

About EN2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:155,458,129-155,464,831 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues, 3 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

EN2 Products(1)

mRNA	Protein	Name
NM_001427.4	NP_001418.2	homeobox protein engrailed-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EN2 Protein Structure

Homeobox

Engrail_1_C_sig

0
100
200
300
333 a.a.

Protein Preferred Names

Protein Names

homeobox protein engrailed-2

engrailed homolog 2

Related Diseases

Diseases

Alias

Cerebellar Hypoplasia

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Hyperinsulinemic Hypoglycemia, Familial, 4

Hyperinsulinism Due To Glutamodehydrogenase Deficiency	HHF4
Familial Hyperinsulinemic Hypoglycemia 4	Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hyperinsulinism Due To Schad Deficiency	Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Congenital Hyperinsulinism	Schad Deficiency
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Keratomalacia

Vitamin A Deficiency	Night Blindness
Retinol Deficiency	Xerotic Keratitis
VAD	Vitamin A
Hypovitaminosis A	Bitot Spots
Bitot Spots In The Young Child	Conjunctival Xerosis With Bitot'S Spots
Vitamin A Deficiency With Cornea Xerosis	Vitamin A Deficiency With Cornea Ulceration Or Xerosis

Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome	Caudal Regression Sequence
Sacral Agenesis	Caudal Dysgenesis Syndrome
SDAM	Caudal Dysplasia Sequence
Caudal Dysplasia	Sacral Agenesis Syndrome
Sacral Regression Syndrome	Sacral Defect And Anterior Sacral Meningocele
Rudd Klimek Syndrome	Sirenomelia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04366	EN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N1024	11R,12-Dihydroxyspirovetiv-1(10)-en-2-one		/	Unkown
HY-N1024A	11S,12-Dihydroxyspirovetiv-1(10)-en-2-one		/	Unkown
HY-N1759	3,11,12-Trihydroxyspirovetiv-1(10)-en-2-one		/	Unkown
HY-N9018	4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EN2	VGNC	VGNC:51801
Bos taurus	EN2	VGNC	VGNC:106724
Felis catus	EN2	VGNC	VGNC:102580
Rattus norvegicus	EN2	RGD	RGD:1561842
Mus musculus	EN2	MGD	MGI:95390
Macaca mulatta	EN2	VGNC	VGNC:108398
Macaca fascicularis	EN2	NCBI	NCBI:102116747
Others	EN2	NCBI

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