ENDOG - endonuclease G Gene

Homo sapiens

Gene ID: 2021 | Gene type: protein coding

About ENDOG

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,818,500-128,822,676 (from NCBI)

This gene has 1 transcript (splice variant), 180 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 10.6), prostate (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear encoded Endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among Animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA Polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

ENDOG Products(1)

mRNA	Protein	Name
NM_004435.2	NP_004426.2	endonuclease G, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	25355512	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	33473107	GOA
involved in mitochondrial DNA catabolic process	IMP IMP: Inferred from mutant phenotype	29719607	GOA
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	33473107	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	33473107	GOA
involved in positive regulation of mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	29719607	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	33473107	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENDOG Protein Structure

Endonuclease_NS

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

endonuclease G, mitochondrial

endo G

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04371	ENDOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ENDOG	VGNC	VGNC:61859
Bos taurus	ENDOG	VGNC	VGNC:28491
Mus musculus	ENDOG	MGD	MGI:1261433
Macaca mulatta	ENDOG	VGNC	VGNC:72218
Rattus norvegicus	ENDOG	RGD	RGD:1310763
Canis familiaris	ENDOG	VGNC	VGNC:40360
Others	ENDOG	NCBI

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