Scn10a - sodium channel, voltage-gated, type X, alpha Gene

Mus musculus

Also known as PN3; SNS; Nav1.8

Gene ID: 20264 | Gene type: protein coding

About Scn10a

Chromosome 9: 119,437,522-119,548,388 reverse strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 331 orthologues, 26 paralogues and is associated with 18 phenotypes. Biased expression in heart adult (RPKM 1.), CNS E18 (RPKM .5) and 9 other tissues.

Summary

Enables voltage-gated Sodium Channel activity. Acts upstream of or within cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Apr 2022]

Scn10a Products(2)

mRNA	Protein	Name
NM_009134.3	NP_033160.2	sodium channel protein type 10 subunit alpha isoform 2
NM_001205321.1	NP_001192250.1	sodium channel protein type 10 subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	16029194	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	24440715	MGI
acts upstream of or within cardiac conduction	IMP IMP: Inferred from mutant phenotype	20062061	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	25101983	MGI
involved in detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	25101983	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	19931571	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	16029194	MGI
acts upstream of or within regulation of atrial cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	20062061	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	16029194	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in C-fiber	IDA IDA: Inferred from direct assay	16029194	MGI
located in axon	IDA IDA: Inferred from direct assay	16029194	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16029194	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn10a Protein Structure

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
1957 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 10 subunit alpha

peripheral nerve sodium channel 3	sensory neuron sodium channel
sodium channel protein type X subunit alpha	voltage gated sodium channel
voltage-gated sodium channel subunit alpha Nav1.8

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12519	SCN10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12520	Scn10a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12521	Scn10a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn10a	NCBI	NCBI:6336

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