LGI3 - leucine rich repeat LGI family member 3 Gene

Homo sapiens

Also known as LGIL4; IDDMDS

Gene ID: 203190 | Gene type: protein coding

About LGI3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,146,830-22,156,806 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 22 paralogues. Biased expression in brain (RPKM 29.1), lung (RPKM 12.3) and 4 other tissues.

Summary

Predicted to enable catalytic activity. Predicted to be involved in regulation of exocytosis. Predicted to be located in extracellular region. Predicted to be active in synaptic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

LGI3 Products(1)

mRNA	Protein	Name
NM_139278.4	NP_644807.1	leucine-rich repeat LGI family member 3 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	35948005	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGI3 Protein Structure

LRR_8

EPTP

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat LGI family member 3

LGI1-like protein 4

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Muscle Tone Abnormalities And Distal Skeletal Defects

IDDMDS

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Peripheral Nerve Hyperexcitability Syndrome	Ataxia, Episodic
Isaacs Neuromyotonia	Continuous Muscle Fibre Activity

Arthrogryposis Multiplex Congenita-1

Epilepsy, Familial Temporal Lobe, 3

Epilepsy, Familial Mesial Temporal Lobe	Fmtle
Familial Temporal Lobe Epilepsy 3	ETL3
Familial Mesial Temporal Lobe Epilepsy

Epilepsy, Familial Temporal Lobe, 1

ETL1	Adpeaf
Adlte	Epilepsy, Partial, With Auditory Features
Autosomal Dominant Partial Epilepsy With Auditory Features	Epilepsy, Lateral Temporal Lobe, Autosomal Dominant
Familial Temporal Lobe Epilepsy 1	Partial Epilepsy With Auditory Features
Autosomal Dominant Lateral Temporal Lobe Epilepsy	Lateral Temporal Lobe Epilepsy Autosomal Dominant
Epilepsy, Temporal Lobe, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07615	LGI3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGI3	RGD	RGD:1311079
Macaca mulatta	LGI3	VGNC	VGNC:74079
Bos taurus	LGI3	VGNC	VGNC:30858
Canis familiaris	LGI3	VGNC	VGNC:42652
Felis catus	LGI3	VGNC	VGNC:63219
Mus musculus	LGI3	MGD	MGI:2182619

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