2. Gene
  3. Sele - selectin, endothelial cell Gene

Sele - selectin, endothelial cell Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Elam; CD62E; ELAM-1; LECAM2; E-selectin

Gene ID: 20339 | Gene type: protein coding

About Sele

Summary

Predicted to enable several functions, including oligosaccharide binding activity; Phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (Selectin E). [provided by Alliance of Genome Resources, Apr 2022]

Sele Products(1)

mRNA Protein Name
NM_011345.3 NP_035475.2 E-selectin precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of leukocyte migration IGI
IGI: Inferred from genetic interaction
17114491 MGI
acts upstream of or within positive regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
17114491 MGI
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
10894166 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E-selectin

CD62 antigen-like family member E

endothelial leukocyte adhesion molecule 1

leukocyte-endothelial cell adhesion molecule 2

Recombinant Sele Proteins

Cat. No. Product Name Accession Purity
HY-P73041 E-Selectin/CD62E Protein, Mouse (HEK293, Fc) NP_035475.1 (W22-P557) ≥95%
HY-P73042 E-Selectin/CD62E Protein, Mouse (HEK293, His) NP_035475.1 (W22-P564) ≥95%
HY-P74160 E-Selectin/CD62E Protein, Mouse (HEK293) NP_035475.1 (W22-P557) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12632 SELE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sele NCBI NCBI:6401
Macaca fascicularis Sele NCBI NCBI:102143564
Rattus norvegicus Sele NCBI NCBI:25544
Macaca mulatta Sele NCBI NCBI:701538