2. Gene
  3. Selp - selectin, platelet Gene

Selp - selectin, platelet Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Grmp; CD62P; LECAM3; PADGEM; GMP-140

Gene ID: 20344 | Gene type: protein coding

About Selp

Summary

Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (Selectin P). [provided by Alliance of Genome Resources, Apr 2022]

Selp Products(1)

mRNA Protein Name
NM_011347.2 NP_035477.1 P-selectin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent protein binding IDA
IDA: Inferred from direct assay
7524641 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7524641 MGI
enables sialic acid binding IDA
IDA: Inferred from direct assay
8562500 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
7688665 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of leukocyte migration IGI
IGI: Inferred from genetic interaction
17114491 MGI
acts upstream of leukocyte migration IMP
IMP: Inferred from mutant phenotype
17114491 MGI
acts upstream of or within leukocyte migration IMP
IMP: Inferred from mutant phenotype
15484189 MGI
acts upstream of or within leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
15956287 MGI
acts upstream of or within positive regulation of leukocyte migration IGI
IGI: Inferred from genetic interaction
17114491 MGI
acts upstream of or within positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
17114491 MGI
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
10894166 MGI
involved in positive regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
16514062 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8562500 MGI
located in membrane IDA
IDA: Inferred from direct assay
7688665 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

P-selectin

CD62 antigen-like family member P

granule membrane protein 140

leukocyte-endothelial cell adhesion molecule 3

platelet activation dependent granule-external membrane protein

Recombinant Selp Proteins

Cat. No. Product Name Accession Purity
HY-P72408 P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) Q01102 (W42-A709) ≥95%
HY-P73383 P-Selectin Protein, Mouse (HEK293, Fc) Q01102 (W42-A709) ≥95%
HY-P78349 P-Selectin Protein, Mouse (HEK293, His) Q01102 (W42-A709) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12647 SELP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selp NCBI NCBI:6403
Macaca fascicularis Selp NCBI NCBI:102141875
Rattus norvegicus Selp NCBI NCBI:25651
Macaca mulatta Selp NCBI NCBI:701277