Sema3a - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Gene

Mus musculus

Also known as SemD; SEMA1; Semad; coll-1; Hsema-I

Gene ID: 20346 | Gene type: protein coding

About Sema3a

Summary

Enables chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of male gonad development; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including dichotomous subdivision of terminal units involved in salivary gland branching; generation of neurons; and negative regulation of epithelial cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A). [provided by Alliance of Genome Resources, Apr 2022]

Sema3a Products(3)

mRNA	Protein	Name
NM_001243072.1	NP_001230001.1	semaphorin-3A precursor
NM_001243073.1	NP_001230002.1	semaphorin-3A precursor
NM_009152.4	NP_033178.2	semaphorin-3A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	11683995	MGI
enables neuropilin binding	IPI IPI: Inferred from physical interaction	15239958	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23104057	MGI
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	15239958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of axon extension	IDA IDA: Inferred from direct assay	12852851	MGI
acts upstream of axon extension	IGI IGI: Inferred from genetic interaction	12852851	MGI
acts upstream of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	7748561	MGI
acts upstream of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
involved in axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	12435358	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15604101	MGI
acts upstream of or within axonal fasciculation	IMP IMP: Inferred from mutant phenotype	17428830	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in basal dendrite arborization	IGI IGI: Inferred from genetic interaction	22683681	MGI
involved in branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	12372285	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IDA IDA: Inferred from direct assay	17626059	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IGI IGI: Inferred from genetic interaction	17626059	MGI
acts upstream of epithelial cell migration	IDA IDA: Inferred from direct assay	17626059	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in facioacoustic ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP IMP: Inferred from mutant phenotype	21059704	MGI
involved in maintenance of synapse structure	IDA IDA: Inferred from direct assay	24831527	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	24831527	MGI
involved in motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within negative chemotaxis	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within negative regulation of axon extension	IDA IDA: Inferred from direct assay	12852851	MGI
acts upstream of or within negative regulation of axon extension	IGI IGI: Inferred from genetic interaction	12852851	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	7748561	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within negative regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	17626059	MGI
involved in nerve development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
acts upstream of or within nervous system development	IGI IGI: Inferred from genetic interaction	12591607	MGI
involved in neural crest cell migration involved in autonomic nervous system development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in neural crest cell migration involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	19325129	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	21059704	MGI
involved in positive regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in positive regulation of neuron migration	IGI IGI: Inferred from genetic interaction	21828096	MGI
involved in regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	15155748	MGI
acts upstream of or within regulation of heart rate	IMP IMP: Inferred from mutant phenotype	17417650	MGI
acts upstream of or within semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	12591607	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection extension	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in synaptic target recognition	IDA IDA: Inferred from direct assay	22179111	MGI
involved in synaptic target recognition	IMP IMP: Inferred from mutant phenotype	22179111	MGI
involved in trigeminal ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in trigeminal nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in ventral trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	19386662	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	24831527	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	24831527	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22179111	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22179111	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-3A

collapsin-1	sema D
sema III	semaphorin III
semaphorin-D

Sema3a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sema3a	O08665	Nrp1	Mus musculus	P97333	SPR	23104057

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Sema3a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74566	Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, Fc)	O08665 (K26-F546)	≥95%
HY-P78350	Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His)	O08665 (Y21-V772)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103511	TCS1105		99.66%	Unkown
HY-RS12650	SEMA3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema3a	NCBI	NCBI:10371
Rattus norvegicus	Sema3a	NCBI	NCBI:29751

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